Meng Kai, Chen Zixuan, Zhang Yu, Chen Xingyu, Chen Taoying, Song Ya, Jia Xing, Liu Min
Department of Urology, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Med Oncol. 2025 May 3;42(6):192. doi: 10.1007/s12032-025-02744-y.
Renal cell carcinoma (RCC), one of the most common types of kidney cancer, represents a major global health concern due to its increasing incidence and high death rates. While conventional treatment modalities have improved patient outcomes, they often face limitations such as drug resistance, severe adverse effects, and limited efficacy in advanced or metastatic cases. These challenges highlight the urgent need for novel therapeutic approaches to enhance RCC management. Tricetin, a natural flavonoid abundant in cereal plants, has shown promising anticancer activity in various malignancies by inhibiting cancer cell proliferation, migration, and invasion. However, the molecular mechanisms underlying Tricetin's effects on RCC remain poorly understood. In this research, we employed network pharmacology to identify key molecular targets of Tricetin in RCC and evaluated its binding affinity to these targets using molecular docking techniques. Bioinformatics analyses were conducted to predict the potential biological pathways involved. Furthermore, in vitro experiments using RCC cell lines (786-O and ACHN) demonstrated that Tricetin suppresses cell proliferation and migration, likely through modulation of the EGFR/PI3K/Akt signaling pathway. Overall, our findings offer new insights into the therapeutic potential of Tricetin and provide a foundation for developing targeted treatment strategies to improve RCC outcomes.
肾细胞癌（RCC）是最常见的肾癌类型之一，由于其发病率不断上升和死亡率高，已成为全球主要的健康问题。虽然传统治疗方式改善了患者的治疗效果，但它们常常面临诸如耐药性、严重不良反应以及在晚期或转移性病例中疗效有限等局限性。这些挑战凸显了迫切需要新的治疗方法来加强肾细胞癌的管理。三甲沙汀是一种在谷类植物中大量存在的天然黄酮类化合物，通过抑制癌细胞增殖、迁移和侵袭，在各种恶性肿瘤中显示出有前景的抗癌活性。然而，三甲沙汀对肾细胞癌作用的分子机制仍知之甚少。在本研究中，我们采用网络药理学来确定三甲沙汀在肾细胞癌中的关键分子靶点，并使用分子对接技术评估其与这些靶点的结合亲和力。进行了生物信息学分析以预测潜在涉及的生物学途径。此外，使用肾细胞癌细胞系（786 - O和ACHN）的体外实验表明，三甲沙汀可能通过调节EGFR/PI3K/Akt信号通路抑制细胞增殖和迁移。总体而言，我们的研究结果为三甲沙汀的治疗潜力提供了新的见解，并为开发改善肾细胞癌治疗效果的靶向治疗策略奠定了基础。
