Li Jiani, Wang Meng, Yang Jing, Cao Zhiwei, Gu Zhaowei, Wang Yunxiu
Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, People's Republic of China.
Clin Rev Allergy Immunol. 2025 May 5;68(1):46. doi: 10.1007/s12016-025-09058-x.
Enhancer of zeste homolog 2 (EZH2), a protein encoded by the EZH2 gene, is a crucial subunit in polycomb repressive complex 2. EZH2 controls the transcription of genes critical for cell proliferation, differentiation, amplification, and function through both methylated and unmethylated functions. EZH2 is considered to be a transcriptional suppressor protein when it controls histone methylation. Its dysregulation is related to a variety of cancers, with significant evidence showing its role in prostate cancer and breast cancer. EZH2 is also thought to be involved in the differentiation and function of immune cells. Ongoing research on EZH2 has revealed the correlation between inflammatory nasal diseases, the occurrence and development of nasal sinus tumors, and EZH2. This article aimed to review the research progress on the role of EZH2 in nasal diseases and explore the possibility of future EZH2-targeted therapies for nasal diseases.
zeste 同源物 2 增强子（EZH2）是由 EZH2 基因编码的一种蛋白质，是多梳抑制复合物 2 中的关键亚基。EZH2 通过甲基化和非甲基化功能控制对细胞增殖、分化、扩增和功能至关重要的基因的转录。当 EZH2 控制组蛋白甲基化时，它被认为是一种转录抑制蛋白。其失调与多种癌症相关，有大量证据表明其在前列腺癌和乳腺癌中的作用。EZH2 也被认为参与免疫细胞的分化和功能。对 EZH2 的 ongoing 研究揭示了炎症性鼻病、鼻窦肿瘤的发生发展与 EZH2 之间的相关性。本文旨在综述 EZH2 在鼻部疾病中作用的研究进展，并探讨未来针对 EZH2 的鼻部疾病治疗的可能性。 （注：“ongoing”常见释义为“正在进行的” ，这里直译为“ongoing”，可能是原文有特定语境含义未准确翻译过来，但按要求未做修改）
