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维生素对艾氏腹水癌细胞中脂质过氧化作用及阿霉素诱导的DNA合成抑制的影响。

Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells.

作者信息

Okamoto K, Ogura R

出版信息

J Nutr Sci Vitaminol (Tokyo). 1985 Apr;31(2):129-37. doi: 10.3177/jnsv.31.129.

DOI:10.3177/jnsv.31.129
PMID:4032070
Abstract

The effects of various vitamins on lipid peroxidation and the suppression of DNA synthesis induced by adriamycin (ADR) in vitro using Ehrlich ascites carcinoma (EAC) cells were studied. ADR produced a concentration-dependent stimulation of lipid peroxidation in EAC cells. alpha-Tocopherol and coenzyme Q10 inhibited ADR-induced lipid peroxidation to about the same extent and these effects were the greatest for all antioxidants added. The inhibitory effect of riboflavin 2',3',4',5'-tetrabutyrate was greater than that of riboflavin 5'-phosphate. On measuring incorporation of [3H]thymidine into EAC cells, these vitamins did not alter appreciably the magnitude of the ADR-induced suppression of DNA synthesis in EAC cells.

摘要

研究了多种维生素对体外使用艾氏腹水癌细胞（EAC）的阿霉素（ADR）诱导的脂质过氧化和DNA合成抑制的影响。ADR在EAC细胞中产生浓度依赖性的脂质过氧化刺激作用。α-生育酚和辅酶Q10对ADR诱导的脂质过氧化的抑制程度大致相同，且在所有添加的抗氧化剂中这些作用最为显著。核黄素2',3',4',5'-四丁酸酯的抑制作用大于核黄素5'-磷酸酯。在测量[3H]胸苷掺入EAC细胞的情况时，这些维生素并未明显改变ADR诱导的EAC细胞DNA合成抑制的程度。

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Effect of adriamycin on DNA, RNA and protein biosyntheses in mouse tissues, in connection with its cardiotoxicity.阿霉素对小鼠组织中DNA、RNA和蛋白质生物合成的影响及其心脏毒性
Jpn J Cancer Res. 1989 Oct;80(10):1000-5. doi: 10.1111/j.1349-7006.1989.tb01640.x.