Blueberry pomace is a valuable source of a wide range of active compounds and nutrients and is receiving increasing research attention. However, limited attention has been paid in the literature to the nutritional properties and practical applications of blueberry pomace. In this paper, we review the methods used to extract bioactive compounds from blueberry pomace, study their health effects and explore the prospects for their application in the food industry, such as fermented beverages, nutritional supplements or natural colors. In addition, recent studies have examined the content of various active ingredients such as flavonoids, vitamins, and dietary fiber and suggested the validity of the corresponding extraction methods. In addition, these compounds have great potential in human health, such as antioxidant, hypoglycemic, improvement of cognitive impairment and gut health. This analysis also highlights the bioavailability of the active ingredients in blueberry pomace. Thus, blueberry pomace offers a wide field of scientific and technological exploration, but significant challenges must be faced in order to optimize its utilization and promote further research on extraction, applications, and innovative methods.