Alqahtani Nashi K, Alnemr Tareq M, Farag Hoda A S, Ismail Rania, Habib Hosam M
Department of Food and Nutrition Sciences, College of Agricultural and Food Sciences, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.
Date Palm Research Center of Excellence, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.
Food Chem X. 2025 Apr 19;27:102480. doi: 10.1016/j.fochx.2025.102480. eCollection 2025 Apr.
This study investigated the antioxidant and biomolecular shielding effects of polyphenol-rich extracts from 18 date palm pit varieties. Phytochemical profiling revealed significant varietal differences, with catechin (358.48 mg/100 g in Maghool) and gallic acid (34.55 mg/100 g in Khalas) as dominant compounds. Antioxidant assays demonstrated robust activity, with Shikat alkahlas showing 64.10 % DPPH inhibition and Maghool exhibiting the highest FRAP value (190.57 mmol Fe/100 g). Enzyme inhibition varied widely: Maghool inhibited tyrosinase by 65.40 %, while Shabebe showed 42.21 % α-amylase inhibition. Protective effects against DNA and BSA damage were pronounced in Sagay (39.99 % supercoiled DNA retention) and Jabri (98.95 % BSA protection). An XGBoost model predicted antioxidant, enzyme inhibitory, and protective activities with up to 92.57 % accuracy, identifying catechin and cinnamic acid as key predictors. These findings underscore the potential of date pits as sustainable sources of bioactive compounds for nutraceutical and pharmaceutical applications.
本研究调查了18个枣椰树果核品种中富含多酚的提取物的抗氧化和生物分子屏蔽作用。植物化学分析显示出显著的品种差异，儿茶素（在Maghool品种中含量为358.48毫克/100克）和没食子酸（在Khalas品种中含量为34.55毫克/100克）为主要化合物。抗氧化分析表明具有强大的活性，Shikat alkahlas品种对DPPH的抑制率为64.10%，Maghool品种的铁还原抗氧化能力（FRAP）值最高（190.57毫摩尔铁/100克）。酶抑制作用差异很大：Maghool品种对酪氨酸酶的抑制率为65.40%，而Shabebe品种对α-淀粉酶的抑制率为42.21%。Sagay品种（超螺旋DNA保留率为39.99%）和Jabri品种（对牛血清白蛋白的保护率为98.95%）对DNA和牛血清白蛋白损伤具有显著的保护作用。一个极端梯度提升（XGBoost）模型预测抗氧化、酶抑制和保护活性的准确率高达92.57%，确定儿茶素和肉桂酸为关键预测因子。这些发现强调了枣椰树果核作为营养保健品和制药应用中生物活性化合物可持续来源的潜力。
