Alihajdaraj Rrezarta, Krasniqi Xhevdet, Sadikaj Antigona Kabashi, Xhuxha Granit, Lahu Vendenis, Avdiu Shqipdon, Jashari Kreshnik, Kadriaj Jehona Ismaili, Bakalli Aurora
Clinic of Rheumatology, University Clinical Center of Kosova, Pristina, Kosovo.
Medical Faculty, University of Prishtina, Pristina, Kosovo.
Radiol Case Rep. 2024 Oct 10;20(1):91-96. doi: 10.1016/j.radcr.2024.09.123. eCollection 2025 Jan.
Ankylosing spondylitis is a chronic inflammatory disease that belongs to the group of seronegative spondyloarthropathies. Rheumatic fever is an abnormal immune response to group A Streptococcus infections. Severe or recurrent episodes of rheumatic fever can lead to significant morbidity and mortality, often resulting in the development of rheumatic heart disease. We present a unique case of a 50-year-old patient who suffered from rheumatic fever during childhood, which was complicated by mitral stenosis. He underwent surgical mitral valve replacement at the age of 35. At 47, he was diagnosed with ankylosing spondylitis following a 3-year history of worsening symptoms. This is the first case in the medical literature describing a patient with mitral stenosis postrheumatic fever coexisting with ankylosing spondylitis. A microbial infection triggering the autoimmune system in genetically susceptible individuals may be the underlying mechanism. However, further research is needed to fully understand the converging pathways of these 2 diseases.
强直性脊柱炎是一种慢性炎症性疾病，属于血清阴性脊柱关节病。风湿热是对A组链球菌感染的异常免疫反应。严重或反复发作的风湿热可导致显著的发病率和死亡率，常导致风湿性心脏病的发生。我们报告了一例独特的病例，一名50岁患者在儿童时期患风湿热，并发二尖瓣狭窄。他在35岁时接受了二尖瓣置换手术。47岁时，在症状恶化3年后，他被诊断为强直性脊柱炎。这是医学文献中首例描述风湿热后二尖瓣狭窄患者与强直性脊柱炎共存的病例。微生物感染在遗传易感个体中触发自身免疫系统可能是潜在机制。然而，需要进一步研究以充分了解这两种疾病的共同途径。
