Roy Ankita, Ganguly Arpan, Pal Soumyajit, Bhowmick Subhrojyoti, Das Nina
Department of Pharmacology, KPC Medical College and Hospital, Kolkata, West Bengal, India.
Department of Gynaecology & Obstetrics, KPC Medical College and Hospital, Kolkata, West Bengal, India.
Perspect Clin Res. 2025 Apr-Jun;16(2):81-86. doi: 10.4103/picr.picr_78_24. Epub 2024 Nov 6.
One in every 10 women presents with abnormal vaginal discharge in Gynaecology and Obstetrics Department, with the most common cause being candidiasis. Irrational use of antifungal for treatment of this condition leads to antifungal resistance and increase morbidity.
This retrospective study was conducted at the Department of Pharmacology in collaboration of Department of Obstetrics and Gynaecology of the private medical college hospital in Kolkata. One hundred and forty outpatient department prescriptions were screened and included in this study from March 2024 to April 2024, and the prescriptions of the previous 6 months were collected.
The average number of drugs per prescription was 1.1. Antifungals were prescribed in 89.3%, out of which only 8.6% were in accordance with the standard treatment guidelines of management of vaginal candidiasis. The dose of the drug was written in 11.5% of the prescriptions while the duration of treatment was written in 84.9% of the prescriptions. The fungal culture and sensitivity testing was documented in only 10.7% of the prescriptions. 29.5% of the prescriptions had the generic name of the medicines whereas the complete diagnosis was written in only 13.7% of the prescriptions.
This study highlights the commonly encountered errors in prescribing of antifungal drugs in a tertiary care teaching hospital. These errors may lead to irrational prescribing of antifungal and development of antifungal resistance in the long run. Active surveillance in the form of regular prescription audit and organizing regular training workshop for the prescribers will improve the prescribing practice.
在妇产科,每10名女性中就有1人出现异常白带,最常见的原因是念珠菌病。不合理使用抗真菌药物治疗这种疾病会导致抗真菌耐药性并增加发病率。
这项回顾性研究是在加尔各答一家私立医学院附属医院的药理学系与妇产科合作进行的。从2024年3月至2024年4月筛选了140份门诊处方并纳入本研究,并收集了前6个月的处方。
每张处方的平均药物数量为1.1种。89.3%的处方开具了抗真菌药物,其中只有8.6%符合阴道念珠菌病管理的标准治疗指南。11.5%的处方写明了药物剂量,而84.9%的处方写明了治疗持续时间。只有10.7%的处方记录了真菌培养和药敏试验。29.5%的处方写有药物通用名,而只有13.7%的处方写明了完整诊断。
本研究突出了三级护理教学医院在抗真菌药物处方方面常见的错误。这些错误可能导致抗真菌药物的不合理处方,并从长远来看导致抗真菌耐药性的产生。通过定期处方审核和为开处方者组织定期培训研讨会的形式进行积极监测将改善处方实践。