Prehospital Trauma Compendium: Tranexamic Acid in Trauma - A Joint Position Statement and Resource Document of NAEMSP, ACEP, and ACS-COT.

Prehospital use of tranexamic acid (TXA) has grown substantially over the past decade despite contradictory evidence supporting its widespread use. Since the previous guidance document on the prehospital use of TXA for injured patients was published by the National Association of Emergency Medical Services Physicians (NAEMSP), the American College of Surgeons Committee on Trauma (ACS-COT), and the American College of Emergency Physicians (ACEP) in 2016, new research has investigated outcomes of patients who receive TXA in the prehospital setting. To provide updated evidence-based guidance on the use of intravenous TXA for injured patients in the EMS setting, we performed a structured literature review and developed the following recommendations supported by the evidence summarized in the accompanying resource document.