全球肺炎支原体近期的大环内酯类耐药模式：一项系统评价与Meta分析
Recent Macrolide Resistance Pattern of Mycoplasma Pneumonia in the World: A Systematic Review and Meta-Analysis.
作者信息
Darazam Ilad Alavi, Rabiei Mohammad Mahdi, Gharehbagh Farid Javandoust, Hatami Firouze, Shahrokhi Shahrzad, Akhgarzad Ali, Nazhand Hadi Allahverdi, Ebadi Hadi, Zeininasab Amir Hossein, Kazeminia Neda, Lotfollahi Legha, Shojaee Sajad
机构信息
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Public Health. 2025 Mar;54(3):530-541. doi: 10.18502/ijph.v54i3.18246.
BACKGROUND
We aimed to systematically review and analyze the prevalence and pattern of resistance in .
METHODS
We searched authentic scientific sources and databases, and reference lists of relevant articles from Jan 1, 2017, to Jun 1, 2023.
RESULTS
Most of the included studies were conducted in Asia (11470 patients). The overall pooled prevalence was 53% (41%-65%), I2=99.69%; <0.001. While subgroups analyses revealed that the pooled prevalence for America (3 studies), Asia (29 studies), and Europe (3 studies) was 9% (5%-12%), 62% (52%-73%), and 6% (1%-12%), respectively. Twenty-one eligible studies for determining of A2063G and 16 for A2064G were analyzed. Global pooled prevalence was 67% (58%-76%), I2=99.65%; <0.001, and 3% (2%-4%), I2=87.44%; <0.001 for A2063G and A2064G, respectively. Pooled prevalence of A2063G for America, Asia and Europe was 10% (5%-16%), 77% (71%-83%) and 5% (2%-9%), respectively.
CONCLUSION
While the prevalence of macrolide-resistant is quite low in America, it is a great dilemma in East Asia and the low prevalence in most countries could be underestimated. This study revealed an increasing trend in macrolide resistance. Indiscriminate and improper use of macrolides may be a warning in this regard.
背景
我们旨在系统回顾和分析……的耐药性流行情况及模式。
方法
我们检索了真实的科学资料、数据库以及2017年1月1日至2023年6月1日相关文章的参考文献列表。
结果
纳入的大多数研究在亚洲进行（11470例患者）。总体合并患病率为53%（41%-65%），I²=99.69%；P<0.001。亚组分析显示，美洲（3项研究）、亚洲（29项研究）和欧洲（3项研究）的合并患病率分别为9%（5%-12%）、62%（52%-73%）和6%（1%-12%）。对21项确定A2063G的合格研究和16项确定A2064G的研究进行了分析。A2063G和A2064G的全球合并患病率分别为67%（58%-76%），I²=99.65%；P<0.001，以及3%（2%-4%），I²=87.44%；P<0.001。美洲、亚洲和欧洲A2063G的合并患病率分别为10%（5%-16%）、77%（71%-83%）和5%（2%-9%）。
结论
虽然大环内酯类耐药……在美国的患病率相当低，但在东亚却是一个重大难题，而且大多数国家的低患病率可能被低估。本研究揭示了大环内酯类耐药性呈上升趋势。在这方面，大环内酯类药物的滥用和不当使用可能是一个警示。
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