具有抗炎作用的芍药汤治疗溃疡性结肠炎的安全性及有效性：一项Meta分析

Safety and Efficacy of Shaoyao Decoction with Anti-Inflammatory Effect in the Treatment of Ulcerative Colitis: A Meta-Analysis.

作者信息

Zhu Yan, Liu Quanxi

机构信息

Department of Gastroenterology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100039, China.

出版信息

Iran J Public Health. 2025 Mar;54(3):478-488. doi: 10.18502/ijph.v54i3.18241.

DOI:10.18502/ijph.v54i3.18241

PMID:40330184

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12051808/

Abstract

BACKGROUND

We aimed to evaluate the effectiveness and safety of Shaoyao Tang in treating ulcerative colitis (UC) through a randomized controlled meta-analysis.

METHODS

Computer searches were conducted between Jan 2000 and Mar 2023 using the databases of CNKI, VIP, PubMed, the Cochrane Library, Wanfang and Web of Science in search of trials with randomization and control including Shaoyao decoction in UC. After quality assessment, The Revman 5.3 was applied.

RESULTS

Overall, 23 articles were selected for the study totally. Shaoyao decoction improved clinical effective rate (<0.001) and effective rate of syndrome (<0.001), IBDQ (<0.001), interleukin-4 (<0.001) and interleukin-10 (<0.001), reduced adverse reactions (=0.004), recurrence rate (=0.03), DAI (<0.001), tumour necrosis component α (<0.001), interleukin-1β (<0.001), interleukin-6 (<0.001), and extremely sensitive C-reactive protein (=0.02).

CONCLUSION

Shaoyao decoction has certain advantages and good safety in the treatment of UC; however the findings still need to be supported by excellent studies.

摘要

背景

我们旨在通过随机对照荟萃分析评估芍药汤治疗溃疡性结肠炎（UC）的有效性和安全性。

方法

于2000年1月至2023年3月期间进行计算机检索，使用中国知网、维普、PubMed、考克兰图书馆、万方和Web of Science数据库，以查找有关UC中包含芍药汤的随机对照试验。经过质量评估后，应用Revman 5.3软件。

结果

总体而言，共选择23篇文章进行研究。芍药汤提高了临床有效率（<0.001）、证候有效率（<0.001）、炎症性肠病问卷（IBDQ）评分（<0.001）、白细胞介素-4（<0.001）和白细胞介素-10（<0.001），降低了不良反应发生率（=0.004）、复发率（=0.03）、疾病活动指数（DAI）（<0.001）、肿瘤坏死因子α（<0.001）、白细胞介素-1β（<0.001）、白细胞介素-6（<0.001）以及超敏C反应蛋白（=0.02）。