Henneghan Ashley M, Paolillo Emily W, Van Dyk Kathleen M, Franco-Rocha Oscar Y, Patel Mansi, Bang So Hyeon, Moore Raeanne C
School of Nursing, University of Texas at Austin, Austin, TX, United States.
Dell Medical School, Department of Oncology, University of Texas at Austin, Austin, TX, United States.
Front Digit Health. 2025 Apr 22;7:1543846. doi: 10.3389/fdgth.2025.1543846. eCollection 2025.
OBJECTIVE: Breast cancer and its treatment are associated with cancer-related cognitive impairments (CRCI). Cognitive ecological momentary assessments (EMA) allow for the assessment of individual subjective and objective cognitive functioning in real world environments and can be easily administered via smartphones. The objective of this study was to establish the feasibility, reliability, and validity of a cognitive EMA platform, NeuroUX, for assessing CRCI in breast cancer survivors. METHODS: Using a prospective design, clinical cognitive assessments (neuropsychological testing; patient reported outcomes) were collected at baseline, followed by an 8-week EMA smartphone protocol assessing self-reported cognitive concerns and objective cognitive performance via mobile cognitive tests once per day, every other day. Satisfaction and feedback questions were included in follow-up data collection. Feasibility data were analyzed using descriptive methods. Test-retest reliability was examined using intraclass correlation coefficients for each cognitive EMA (tests and self-report questions), and Pearson's correlation was used to evaluate convergent validity between cognitive EMAs and baseline clinical cognitive variables. RESULTS: 105 breast cancer survivors completed the EMA protocol with high adherence (87.3%) and high satisfaction (mean 87%). Intraclass correlation coefficients for all cognitive EMAs were strong (>0.73) and correlational findings indicated moderately strong convergent validity (|0.23| < < |0.61|). CONCLUSION: Fully remote, self-administered cognitive testing for 8-weeks on smartphones was feasible in breast cancer survivors who completed adjuvant treatment and the specific cognitive EMAs (cognitive EMA tests and self-report questions) administered demonstrate strong reliability and validity for CRCI.
目的：乳腺癌及其治疗与癌症相关的认知障碍（CRCI）有关。认知生态瞬时评估（EMA）能够在现实世界环境中评估个体的主观和客观认知功能，并且可以通过智能手机轻松进行。本研究的目的是建立一个认知EMA平台NeuroUX，用于评估乳腺癌幸存者的CRCI的可行性、可靠性和有效性。 方法：采用前瞻性设计，在基线时收集临床认知评估（神经心理学测试；患者报告的结果），随后进行为期8周的EMA智能手机方案，通过移动认知测试每隔一天评估一次自我报告的认知问题和客观认知表现。随访数据收集包括满意度和反馈问题。使用描述性方法分析可行性数据。使用组内相关系数检查每个认知EMA（测试和自我报告问题）的重测信度，并使用Pearson相关性评估认知EMA与基线临床认知变量之间的收敛效度。 结果：105名乳腺癌幸存者完成了EMA方案，依从性高（87.3%），满意度高（平均87%）。所有认知EMA的组内相关系数都很强（>0.73），相关结果表明收敛效度中等强（|0.23|< <|0.61|）。 结论：对于完成辅助治疗的乳腺癌幸存者，在智能手机上进行为期8周的完全远程、自我管理的认知测试是可行的，所采用的特定认知EMA（认知EMA测试和自我报告问题）对CRCI具有很强的可靠性和有效性。
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