Tse Jun Lai, Rebollada-Merino Agustín, Pumarola Martí, Ortiz Ana Liza, Toni Cristina
Neurology and Neurosurgery Service, Willows Veterinary Centre and Referral Service, Solihull, West Midlands, UK.
Department of Population Medicine and Diagnostic Sciences, Section of Anatomic Pathology, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
J Vet Diagn Invest. 2025 Jul;37(4):657-661. doi: 10.1177/10406387251329049. Epub 2025 May 7.
A 7-y-old male neutered crossbreed dog was presented to a veterinary referral hospital with a 9-mo history of progressive non-ambulatory tetraparesis. A magnetic resonance imaging (MRI) study revealed multiple T2-weighted hyperintense intradural nodular lesions within the cervical spinal cord and nerves that were contrast-enhancing in T1-weighted post-contrast images. Neurologic signs progressed despite steroid treatment and a second MRI revealed slight enlargement of the previously seen lesions. The dog was euthanized due to severe neurologic signs. Histopathology and immunohistochemistry (laminin, S100, SOX10) confirmed multiple spindle-cell tumors from cervical spinal nerves, consistent with schwannomas. Neoplastic cells occasionally contained a large, clear vacuole (lipoblast-like change). The clinical and pathologic presentation resembles schwannomatosis, a hereditary condition in humans.
一只7岁已绝育的杂交雄性犬因进行性非行走性四肢轻瘫9个月病史被送至一家兽医转诊医院。磁共振成像（MRI）研究显示，颈脊髓和神经内有多个T2加权高信号硬膜内结节性病变，在T1加权增强后图像中呈对比增强。尽管进行了类固醇治疗，神经症状仍进展，第二次MRI显示先前所见病变略有增大。该犬因严重神经症状实施安乐死。组织病理学和免疫组织化学（层粘连蛋白、S100、SOX10）证实颈脊神经有多发性梭形细胞瘤，符合神经鞘瘤。肿瘤细胞偶尔含有一个大的透明空泡（成脂细胞样改变）。临床和病理表现类似于人类的遗传性疾病神经鞘瘤病。
