Guenzet J, Bourin M, Laurent D, Aminou T
Methods Find Exp Clin Pharmacol. 1985 May;7(5):259-68.
A general theory of haemoperfusion for drugs obeying the one-compartment pharmacokinetics model is proposed. The following theoretical cases are investigated: First case Adsorption and desorption are first-order reactions without biotransformation, and elimination rate is first-order. Two particular cases are examined: no desorption and alpha = beta. Second case: Adsorption and desorption rates are first-order, without biotransformation, and elimination rate is zero-order. Third case: Adsorption rate is first-order and desorption rate is zero-order, without biotransformation, and elimination is either first-order or zero-order. Fourth case Adsorption rate is zero-order and desorption rate is first-order, without biotransformation, and elimination is either first-order or zero-order. Fifth case: Adsorption and desorption rates are first-order, with biotransformation. In all these pharmacokinetics models for haemoperfusion, theoretical computations lead to the values of adsorbed amount and plasma level, in relation to time. Clearances are also computed. In most cases, haemoperfusion must be performed quickly because of the desorption phenomenon. Parameters modulating the adsorption process are: surface area, blood flow, drug concentration in blood, adsorbent nature and adsorbent quantity.
提出了一种适用于服从单室药代动力学模型药物的血液灌流通用理论。研究了以下理论情况：第一种情况：吸附和解吸为无生物转化的一级反应，消除速率为一级。考察了两个特殊情况：无脱附以及α = β。第二种情况：吸附和解吸速率为一级，无生物转化，消除速率为零级。第三种情况：吸附速率为一级，解吸速率为零级，无生物转化，消除为一级或零级。第四种情况：吸附速率为零级，解吸速率为一级，无生物转化，消除为一级或零级。第五种情况：吸附和解吸速率为一级，有生物转化。在所有这些血液灌流的药代动力学模型中，理论计算得出了与时间相关的吸附量和血浆水平值。还计算了清除率。在大多数情况下，由于解吸现象，必须快速进行血液灌流。调节吸附过程的参数有：表面积、血流量、血液中的药物浓度、吸附剂性质和吸附剂数量。
