Sun Qiyuan, Wu Mingmin, Xie Runxia, Lai Lingfeng, Chen Qiujie, Guan Jitian
Department of Medical Imaging, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, China.
Department of Radiology, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China.
ACS Chem Neurosci. 2025 May 21;16(10):1838-1846. doi: 10.1021/acschemneuro.5c00008. Epub 2025 May 7.
This review aims to explore the potential application of α-synuclein (α-syn) molecular probes in the early diagnosis of Parkinson's disease (PD), particularly through systematic evaluation using medical imaging methods. In recent years, The abnormal aggregation of α-syn within the central nervous system is now recognized as a central driver of PD pathophysiology, solidifying its role as a critical diagnostic and prognostic biomarker. Early diagnosis of PD is critical for enabling precision therapeutic interventions and mitigating neurodegenerative progression, thereby enhancing long-term functional outcomes and the quality of life. However, challenges remain in clinical practice, particularly concerning the late timing of diagnosis and the lack of specific biomarkers. By analyzing the existing literature, we will assess the effectiveness of different imaging techniques combined with α-syn probes and discuss their advantages and limitations in clinical applications. These imaging methods can provide visualization of early pathological changes, helping to improve the recognition rate of PD. Finally, we emphasize the importance of future research to explore new molecular probes and imaging technologies that can improve early diagnosis rates and treatment outcomes for PD.
本综述旨在探讨α-突触核蛋白（α-syn）分子探针在帕金森病（PD）早期诊断中的潜在应用，特别是通过医学成像方法进行系统评估。近年来，α-syn在中枢神经系统内的异常聚集现已被认为是PD病理生理学的核心驱动因素，巩固了其作为关键诊断和预后生物标志物的作用。PD的早期诊断对于实现精准治疗干预和减轻神经退行性进展至关重要，从而提高长期功能结局和生活质量。然而，临床实践中仍然存在挑战，特别是诊断时间较晚以及缺乏特异性生物标志物。通过分析现有文献，我们将评估不同成像技术与α-syn探针结合的有效性，并讨论它们在临床应用中的优缺点。这些成像方法可以提供早期病理变化的可视化，有助于提高PD的识别率。最后，我们强调未来研究探索能够提高PD早期诊断率和治疗效果的新分子探针和成像技术的重要性。
