Ha Junseo, Sung Suchan, Kim Hyeonwoo
Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Ann Pediatr Endocrinol Metab. 2025 Apr;30(2):59-68. doi: 10.6065/apem.2448218.109. Epub 2025 Apr 30.
Exercise is known to promote physical health and reduce the risk of various diseases. During exercise, skeletal muscle actively contracts to perform movements and secretes hormone-like molecules termed myokines. The beneficial effects of exercise have been assessed with respect to myokine production, and those of irisin on bone, adipose tissue, and the brain have been well documented. Irisin, through its interactions with the integrin αV family, plays a crucial role in bone maintenance, metabolic regulation, and cognitive function. Building on the established understanding of irisin, this discussion will examine the functions and effects of other myokines as key secretory factors in exercise, emphasizing their broader roles in health promotion and the potential for new therapeutic strategies in disease prevention and treatment.
众所周知，运动可促进身体健康并降低患各种疾病的风险。在运动过程中，骨骼肌积极收缩以执行动作，并分泌被称为肌动蛋白的激素样分子。运动的有益效果已根据肌动蛋白的产生进行了评估，鸢尾素对骨骼、脂肪组织和大脑的有益效果已有充分记录。鸢尾素通过与整合素αV家族相互作用，在骨骼维持、代谢调节和认知功能中发挥关键作用。基于对鸢尾素的既定认识，本次讨论将探讨其他肌动蛋白作为运动中关键分泌因子的功能和作用，强调它们在促进健康方面的更广泛作用以及在疾病预防和治疗中采用新治疗策略的潜力。
