Li Fei, Wang Yuetang, Xu Donghui, Wang Xu, Wang Wei
Heart Valve and Atrial Fibrillation Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of Structural Heart Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Ann Thorac Cardiovasc Surg. 2025;31(1). doi: 10.5761/atcs.oa.24-00152.
PURPOSE: This study aimed to summarize 8-year clinical outcomes for patients who underwent transcatheter aortic valve replacement (TAVR) with the J-Valve system and evaluate the long-term durability and hemodynamic performance of the valve. METHODS: Between July 2014 and June 2015, 21 patients underwent transapical TAVR with the J-Valve system. Systematic clinical and echocardiographic follow-up was conducted on 18 patients for up to 8 years. RESULTS: Eight years post-TAVR with the J-Valve system, the all-cause mortality rate was 16.7%, with no prosthesis failures or thrombosis. Moderate to severe valve deterioration was observed in 50% of patients with aortic stenosis (AS), whereas no such deterioration was noted in patients with pure aortic regurgitation (PAR). At 8 years following TAVR, the effective orifice area measured 2.27 ± 0.50 cm in patients with PAR and 1.35 ± 0.38 cm in those with AS. Additionally, patients with AS exhibited a mean pressure gradient of 17.90 ± 10.61 mmHg. Over 8 years, PAR patients experienced a significant reduction in left ventricular end-diastolic diameter from 61.50 ± 2.08 mm to 48.67 ± 7.23 mm (p < 0.001), whereas AS patients showed no significant change. CONCLUSION: The J-Valve system demonstrates favorable long-term outcomes in TAVR, with excellent durability and hemodynamic performance in PAR patients.
目的:本研究旨在总结接受J-Valve系统经导管主动脉瓣置换术(TAVR)患者的8年临床结局,并评估该瓣膜的长期耐用性和血流动力学性能。 方法:2014年7月至2015年6月期间,21例患者接受了使用J-Valve系统的经心尖TAVR。对18例患者进行了长达8年的系统临床和超声心动图随访。 结果:使用J-Valve系统进行TAVR术后8年,全因死亡率为16.7%,未发生人工瓣膜故障或血栓形成。在50%的主动脉瓣狭窄(AS)患者中观察到中度至重度瓣膜退化,而在单纯主动脉瓣反流(PAR)患者中未观察到此类退化。TAVR术后8年,PAR患者的有效瓣口面积为2.27±0.50平方厘米,AS患者为1.35±0.38平方厘米。此外,AS患者的平均压力阶差为17.90±10.61毫米汞柱。在8年期间,PAR患者的左心室舒张末期直径从61.50±2.08毫米显著减小至48.67±7.23毫米(p<0.001),而AS患者无显著变化。 结论:J-Valve系统在TAVR中显示出良好的长期结局,在PAR患者中具有出色的耐用性和血流动力学性能。
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