Sun Xin, Chen Zhuoxi, Yang Hui, Yu Jianing, Lin Haiyan, Zhang Leiming
School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, 264003, China.
The Second School of Clinical Medicine, Binzhou Medical University, Yantai, 264100, China.
Apoptosis. 2025 May 7. doi: 10.1007/s10495-025-02120-1.
Cervical cancer (CC) is a prevalent malignant tumor in the female reproductive system, with rising incidence rates among younger women posing a significant public health challenge. Human papillomavirus (HPV) infection is the primary cause, driving carcinogenesis by promoting abnormal proliferation of tumor cells. Ferroptosis is a form of regulated necrosis that is caused by an iron-dependent accumulation of lipid peroxides with rupture of the plasma membrane. Targeting ferroptosis-related molecules and pathways can selectively induce cervical cancer cell death, while alterations in the expression of ferroptosis-related genes provide promising biomarkers for prognostic assessment. Advances in research on biomarkers and molecular targets are improving predictions of therapeutic outcomes, overcoming drug resistance, and optimizing immunotherapy strategies, thereby opening new avenues for precision medicine. This review focuses on the molecular mechanisms underlying ferroptosis in cervical cancer, discusses its potential applications in early diagnosis and prognosis evaluation, and summarizes the latest advancements in targeted therapy, aiming to provide a novel perspective for the clinical management of cervical cancer.
宫颈癌（CC）是女性生殖系统中一种常见的恶性肿瘤，年轻女性发病率不断上升，这对公共卫生构成了重大挑战。人乳头瘤病毒（HPV）感染是主要病因，通过促进肿瘤细胞异常增殖驱动癌变。铁死亡是一种程序性坏死形式，由铁依赖性脂质过氧化物积累导致质膜破裂引起。靶向铁死亡相关分子和途径可选择性诱导宫颈癌细胞死亡，而铁死亡相关基因表达的改变为预后评估提供了有前景的生物标志物。生物标志物和分子靶点研究的进展正在改善对治疗结果的预测、克服耐药性并优化免疫治疗策略，从而为精准医学开辟新途径。本综述聚焦宫颈癌中铁死亡的分子机制，讨论其在早期诊断和预后评估中的潜在应用，并总结靶向治疗的最新进展，旨在为宫颈癌的临床管理提供新视角。
