Nishino Takato, Shimbo Masaki, Fukagawa Eri, Narimoto Kazutaka, Hashimoto Jun, Ogita Shin, Kanomata Naoki, Hattori Kazunori, Endo Fumiyasu
Department of Urology St. Luke's International Hospital Chuo-ku Japan.
Department of Medical Oncology St. Luke's International Hospital Chuo-ku Japan.
IJU Case Rep. 2025 Mar 11;8(3):231-235. doi: 10.1002/iju5.70013. eCollection 2025 May.
Solitary fibrous tumors originating in the bladder are extremely rare. While generally associated with favorable outcomes, some show invasive behavior. We report a case of a solitary fibrous tumor originating in the bladder that was treated with multimodal therapy.
A 68-year-old male presented with urinary retention. Imaging revealed a well-defined 6.0 cm mass compressing the prostate. A biopsy suggested stromal sarcoma. Robot-assisted cystoprostatectomy was performed. Pathological examination revealed a solitary fibrous tumor originating from the bladder invading the prostate. Despite negative margins, lung nodules and a pelvic mass appeared 43 months postoperatively. Initially, these were treated with pazopanib, followed by doxorubicin and eribulin due to disease progression. The patient eventually transitioned to palliative care and passed away 69 months after diagnosis.
There are no effective systemic treatments for solitary fibrous tumors, which can lead to poor outcomes. Individualized treatment approaches are necessary.
起源于膀胱的孤立性纤维瘤极为罕见。虽然总体预后良好，但有些会表现出侵袭性行为。我们报告一例起源于膀胱的孤立性纤维瘤，采用多模式治疗。
一名68岁男性因尿潴留就诊。影像学检查显示一个边界清晰的6.0厘米肿块压迫前列腺。活检提示为间质肉瘤。行机器人辅助膀胱前列腺切除术。病理检查显示起源于膀胱并侵犯前列腺的孤立性纤维瘤。尽管切缘阴性，但术后43个月出现肺结节和盆腔肿块。最初，这些病变用帕唑帕尼治疗，由于疾病进展，随后使用阿霉素和艾瑞布林治疗。患者最终转为姑息治疗，诊断后69个月去世。
对于孤立性纤维瘤没有有效的全身治疗方法，这可能导致不良预后。个体化治疗方法是必要的。
