Overduin Michael, Bhat Rakesh, Dieudonné Thibaud, Zhang Peijun, Kervin Troy A
Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Canada; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.
Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Canada.
Curr Opin Struct Biol. 2025 Jun;92:103061. doi: 10.1016/j.sbi.2025.103061. Epub 2025 May 7.
Each cell possesses a genetic and a proteolipid code that together convey molecular information in a perpetual cycle. One element of this cycle is the recognition of lipids that work together to specify subcellular locations for biochemical activity. These "lipidons" are now being resolved in protein structures from eukaryotic plasma membranes, endosomes, mitochondria, prokaryotes, and viruses with technologies like in situ cryo-electron imaging and membrane-active polymers. This adds to an expanding catalogue of codified protein-lipid interactions that are recontextualizing cell biology and drug discovery.
每个细胞都拥有一个遗传密码和一个蛋白脂质密码，它们共同以一个永不停息的循环传递分子信息。这个循环的一个要素是对脂质的识别，这些脂质共同作用以指定生化活动的亚细胞位置。现在，利用原位冷冻电子成像和膜活性聚合物等技术，正在真核细胞质膜、内体、线粒体、原核生物和病毒的蛋白质结构中解析出这些“脂质子”。这增加了一个不断扩大的编码蛋白质 - 脂质相互作用的目录，这些相互作用正在重新塑造细胞生物学和药物发现。
