Catalano M, Sacchi E, Tomasini M, Coazzoli E, Parolini A, Dall'Oglio A, Libretti A
Ric Clin Lab. 1985;15 Suppl 1:475-8.
Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
氟桂利嗪是一种长效钙拮抗剂，为评估其对血液粘度、红细胞变形性、血小板活性及一些临床参数的影响，对周围血管疾病患者进行了研究。开展了一项随机双盲研究；所有患者均给予标准饮食，被要求戒烟并进行日常规律运动（散步）。经过2个月的导入期后，患者被分为两组：一组接受10毫克/天氟桂利嗪治疗，另一组接受安慰剂治疗。接受氟桂利嗪治疗的组红细胞滤过时间和血液粘度显著降低，无运动平板间期得到改善，且所考虑的参数之间存在相关性。
