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在仓鼠中补充四种菌株和两种菌株的益生菌混合物后，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染显著减少，恢复情况得到改善。

Marked reduction of SARS-CoV-2 infection and improved recovery following supplementation with a probiotic mix of four strains and two strains of in hamsters.

作者信息

Torres-Maravilla Edgar, Wasniewski Marine, Wauquier Aurélie, Servat Alexandre, Picard-Meyer Evelyne, Monchatre-Leroy Elodie, Auger Sandrine, Holowacz Sophie, Boué Franck, Langella Philippe, Jacouton Elsa, Waligora-Dupriet Anne-Judith

机构信息

Université Paris-Saclay, INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.

ANSES, LRFSN, Laboratoire de la rage et de la faune sauvage de Nancy, Malzéville, France.

出版信息

Appl Environ Microbiol. 2025 Jun 18;91(6):e0064825. doi: 10.1128/aem.00648-25. Epub 2025 May 12.

DOI:10.1128/aem.00648-25
PMID:40353655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12175514/
Abstract

UNLABELLED: Only a few studies have shown that certain probiotics have beneficial effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, two strains of , CNCM I-5644 and CNCM I-5979, selected for their immunomodulatory properties demonstrated in a screening of 20 strains and a mixture of 4 probiotic strains selected based on its immunomodulatory and antiviral properties were evaluated in a hamster model of SARS-CoV-2 infection. Supplementation with these probiotics (7 days before plus 7 days after infection) reduced SARS-CoV-2 infection with a significantly reduced viral load in the upper respiratory tract and lungs and improved weight recovery. Probiotics also counteracted the increase in inflammatory markers and intestinal permeability. The impact of these probiotics was independent of microbiota composition and short-chain fatty acid production. Overall, these data suggest that the probiotics tested, in particular the mix containing LA101, LA102, LA103, and LA104, can facilitate recovery from SARS-CoV-2 infection (as shown by weight regain in infected hamsters) by reducing viral load and inflammation. IMPORTANCE: Our study investigated the potential benefits of specific probiotics in fighting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19). We tested two strains of selected based on their immune-boosting properties, along with a commercial mix of four probiotic strains chosen for its antiviral and immune-modulating effects. These probiotics were administered to hamsters over a week before and a week after infection. Supplementation with these probiotics significantly reduced the viral load in the upper respiratory tract and lungs, promoting recovery as demonstrated by the weight regain observed. In addition to reducing viral presence, the probiotics also helped lower inflammation and improved gut health by counteracting increased intestinal permeability. Our findings suggest that probiotics, particularly the mix of four strains, could support recovery from SARS-CoV-2 infection by reducing inflammation, viral load, and enhancing overall health.

摘要

未标注：仅有少数研究表明某些益生菌对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染有有益作用。在本研究中，在对20株菌株进行筛选时因其免疫调节特性而挑选出的两株 ，即法国国家微生物保藏中心（CNCM）I-5644和CNCM I-5979，以及基于其免疫调节和抗病毒特性挑选出的4株益生菌混合菌株，在SARS-CoV-2感染的仓鼠模型中进行了评估。补充这些益生菌（感染前7天加感染后7天）可减少SARS-CoV-2感染，显著降低上呼吸道和肺部的病毒载量，并改善体重恢复情况。益生菌还可对抗炎症标志物的增加和肠道通透性的提高。这些益生菌的作用独立于微生物群组成和短链脂肪酸的产生。总体而言，这些数据表明，所测试的益生菌，特别是含有LA101、LA102、LA103和LA104的混合物，可通过降低病毒载量和炎症促进从SARS-CoV-2感染中恢复（如感染仓鼠体重恢复所示）。 重要性：我们的研究调查了特定益生菌在对抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染（新冠肺炎）方面的潜在益处。我们测试了基于其增强免疫力特性挑选出的两株 ，以及因其抗病毒和免疫调节作用而选择的4株益生菌商业混合物。这些益生菌在感染前一周和感染后一周给予仓鼠。补充这些益生菌显著降低了上呼吸道和肺部的病毒载量，促进了恢复，如观察到的体重恢复所示。除了减少病毒存在外，益生菌还通过对抗肠道通透性增加帮助减轻炎症并改善肠道健康。我们的研究结果表明，益生菌，特别是4株菌株的混合物，可通过减轻炎症、降低病毒载量和增强整体健康来支持从SARS-CoV-2感染中恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de05/12175514/239403fc49c1/aem.00648-25.f006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de05/12175514/e5a95b27ac85/aem.00648-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de05/12175514/8425bc23438a/aem.00648-25.f002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de05/12175514/239403fc49c1/aem.00648-25.f006.jpg

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本文引用的文献

[1]
Rifaximin ameliorates influenza A virus infection-induced lung barrier damage by regulating gut microbiota.

Appl Microbiol Biotechnol. 2024-9-19

[2]
A Cardiolipin from Induces Antigen-Specific Cytokine Responses.

J Am Chem Soc. 2023-11-1

[3]
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Nucleic Acids Res. 2023-7-5

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From In Vitro to In Vivo: A Rational Flowchart for the Selection and Characterization of Candidate Probiotic Strains in Intestinal Disorders.

Microorganisms. 2023-3-30

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Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome.

Sci Rep. 2022-11-17

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Gut Microbes. 2022

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Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters.

Gut Microbes. 2022

[8]
Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial.

Probiotics Antimicrob Proteins. 2023-6

[9]
Protective effects elicited by cow milk fermented with CBAL74 against SARS-CoV-2 infection in human enterocytes.

J Funct Foods. 2021-12

[10]
Mechanisms of SARS-CoV-2 entry into cells.

Nat Rev Mol Cell Biol. 2022-1

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