Will B E, Sutter A R, Offerlin M R
Psychopharmacology (Berl). 1977 Mar 16;51(3):273-7. doi: 10.1007/BF00431635.
Two factorial experiments (brain status x environment x drug) were designed to measure the effects of methamphetamine and enriched experience on recovery after bilateral cortical lesions. Fisher male rats were operated or sham operated when 30 days old and thereafter raised in either an enriched (EC) or impoverished (IC) condition while daily injected with either methampheteamine (2 mg/kg) or saline. In EC, 12 rats lived together in a large cage with stimulus objects that were changed daily. In IC, a rat was kept alone in a small cage. The animals' performance was measured on a standard series of problems in a Hebb-Williams maze. The animals' scores were impaired by removal of tissue from the occipital cortex. Enriched experience, on the contrary, helped significantly in overcoming, at least partially, the effects of brain damage on problem-solving behavior regardless of whether this experience was given, for 2 h per day over a 60-day period (Expt. 1), or for 2 h per day over only a 30-day period (EXPT. 2). No drug effect was found in any of these experiments.
设计了两项析因实验（脑状态×环境×药物）来测量甲基苯丙胺和丰富经历对双侧皮质损伤后恢复的影响。30日龄时，对雄性Fisher大鼠进行手术或假手术，之后将其饲养在丰富环境（EC）或贫乏环境（IC）中，同时每天注射甲基苯丙胺（2毫克/千克）或生理盐水。在丰富环境组中，12只大鼠共同生活在一个大笼子里，笼内有每天更换的刺激物品。在贫乏环境组中，一只大鼠单独饲养在一个小笼子里。通过在标准系列的赫布 - 威廉姆斯迷宫问题上测试动物的表现。从枕叶皮质去除组织会损害动物的得分。相反，丰富的经历至少在一定程度上显著有助于克服脑损伤对解决问题行为的影响，无论这种经历是在60天的时间里每天给予2小时（实验1），还是仅在30天的时间里每天给予2小时（实验2）。在这些实验中均未发现药物效应。
