Xu Zhixiao, Chen Chengshui, Lei Xiong
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Key Laboratory of Interventional Pulmonology of Zhejiang Province, Wenzhou, China.
BMC Psychiatry. 2025 May 12;25(1):479. doi: 10.1186/s12888-025-06924-y.
Recent studies have suggested body mass index (BMI) change patterns in adulthood may be crucial for depression. This purpose of this study is to evaluate the impact of adult BMI change patterns on depression.
The National Health and Nutrition Examination Survey 2007 to 2018 generated the data. The relationships between adult BMI change patterns and depression / Patient Health Questionnaire 9 (PHQ-9) were investigated using logistic regression and generalized linear model with a Poisson distribution. The relationships between BMI change patterns, depressive symptoms, and all-cause mortality were examined by Cox proportional hazards models. Kaplan-Meier curves were employed to illustrate the cumulative incidence over time. To explore whether adult BMI change patterns mediate this link between depression and all-cause mortality, mediation analysis was conducted.
A total of 10,448 participants were included, with 7.8% reporting depression. Significant differences were observed in demographic, lifestyle, and health characteristics across BMI change patterns. The high-increase pattern was linked to a1.61 times greater odds of depression after adjustment (odds ratio = 1.61, 95% confidence interval (CI): [1.16, 2.24], P = 0.006) compared to the non-overweight pattern. Gender and age differences were also observed. The higher PHQ-9 was correlated with increased all-cause mortality risk, even after adjustment (hazard ratio: 1.03; 95%CI: 1.02-1.05). Mediation analysis revealed that adult BMI change patterns mediated 26.98% of the correlation between depressive symptoms and all-cause mortality.
Persistent obesity in adulthood rises the risk of depression, and BMI change patterns playing a modest role in mediating the link between depressive symptoms and all-cause mortality. Early intervention in individuals at-risk BMI change patterns might reduce depression risk. Future research should investigate whether modifying BMI change patterns can lower depression incidence.
Not applicable.
近期研究表明，成年期体重指数（BMI）变化模式可能对抑郁症至关重要。本研究旨在评估成年期BMI变化模式对抑郁症的影响。
数据来自2007年至2018年的国家健康与营养检查调查。使用逻辑回归和泊松分布的广义线性模型研究成年期BMI变化模式与抑郁症/患者健康问卷9（PHQ-9）之间的关系。通过Cox比例风险模型检验BMI变化模式、抑郁症状和全因死亡率之间的关系。采用Kaplan-Meier曲线来说明随时间的累积发病率。为探讨成年期BMI变化模式是否介导抑郁症与全因死亡率之间的这种联系，进行了中介分析。
共纳入10448名参与者，其中7.8%报告有抑郁症。不同BMI变化模式在人口统计学、生活方式和健康特征方面存在显著差异。与非超重模式相比，高增长模式在调整后与抑郁症的患病几率高1.61倍相关（优势比=1.61，95%置信区间（CI）：[1.16, 2.24]，P = 0.006）。还观察到性别和年龄差异。即使在调整后，较高的PHQ-9也与全因死亡风险增加相关（风险比：1.03；95%CI：1.02 - 1.05）。中介分析显示，成年期BMI变化模式介导了抑郁症状与全因死亡率之间26.98%的相关性。
成年期持续肥胖会增加患抑郁症的风险，BMI变化模式在介导抑郁症状与全因死亡率之间的联系中起适度作用。对有风险的BMI变化模式个体进行早期干预可能会降低抑郁症风险。未来研究应调查改变BMI变化模式是否能降低抑郁症发病率。
不适用。
