Ma Dongmei, Li Li, Liu Wei, Xu Jianhong
Department of Anesthesiology, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Front Neurosci. 2025 Apr 28;19:1543421. doi: 10.3389/fnins.2025.1543421. eCollection 2025.
Postoperative pain is a prevalent clinical issue that significantly impacts patient recovery, making its management crucial for rehabilitation. Recent studies have shown that postoperative pain not only affects the physiological state of patients but may also disrupt their circadian rhythms, leading to decreased sleep quality and physiological dysfunctions. This review aims to explore the effects of postoperative pain interventions on circadian rhythm disturbances, analyze the underlying mechanisms, and summarize the effective strategies currently used in clinical practice. Through a comprehensive analysis of the relevant literature, we will highlight the importance of pain management during the recovery process and emphasize its potential role in regulating circadian rhythms. Pharmacological treatments like NSAIDs and melatonin have shown efficacy in regulating circadian rhythms and improving sleep quality in postoperative patients. Multimodal analgesia combining pharmacological and non-pharmacological methods (e.g., CBT, acupuncture) can optimize pain relief while minimizing side effects. However, further research is needed to clarify the bidirectional relationship between pain perception and circadian rhythms and translate these findings into clinical practice.
术后疼痛是一个普遍存在的临床问题，严重影响患者康复，因此对其进行管理对于康复至关重要。最近的研究表明，术后疼痛不仅会影响患者的生理状态，还可能扰乱其昼夜节律，导致睡眠质量下降和生理功能障碍。本综述旨在探讨术后疼痛干预对昼夜节律紊乱的影响，分析其潜在机制，并总结目前临床实践中使用的有效策略。通过对相关文献的全面分析，我们将强调疼痛管理在康复过程中的重要性，并强调其在调节昼夜节律方面的潜在作用。非甾体抗炎药和褪黑素等药物治疗已显示出在调节术后患者昼夜节律和改善睡眠质量方面的疗效。将药物和非药物方法（如认知行为疗法、针灸）相结合的多模式镇痛可以在优化疼痛缓解的同时将副作用降至最低。然而，需要进一步研究以阐明疼痛感知与昼夜节律之间的双向关系，并将这些发现转化为临床实践。
