Witz G, Rao G S, Goldstein B D
Toxicol Appl Pharmacol. 1985 Sep 30;80(3):511-6. doi: 10.1016/0041-008x(85)90396-5.
Toxicological and biochemical effects of muconaldehyde, a six-carbon diene dialdehyde, were evaluated in 6- to 9-week-old CD-1 male mice. The LD50 of trans,trans-muconaldehyde was 6.7 and 7.1 mg/kg body wt when calculated by two different methods. Administration of trans,trans-muconaldehyde (2 mg/kg, ip) daily for 10 and 16 days resulted in a statistically significant decrease in red blood cell count, hematocrit, hemoglobin, bone marrow cellularity, and hepatic total and free sulfhydryl content. There was an increase in white blood cell count and spleen weight at 16 days. Similar effects, but of much lesser magnitude, were observed when the mice were given the same total dose of 2 mg/kg divided into three daily ip injections of 0.67 mg/kg trans,trans-muconaldehyde for 10 and 16 days. This alpha,beta-unsaturated aldehyde is a potent bone marrow toxin in mice.
在6至9周龄的CD-1雄性小鼠中评估了己二烯二醛（一种六碳二烯二醛）的毒理学和生化效应。通过两种不同方法计算，反，反-己二烯二醛的半数致死剂量（LD50）为6.7和7.1毫克/千克体重。每天腹腔注射反，反-己二烯二醛（2毫克/千克），持续10天和16天，导致红细胞计数、血细胞比容、血红蛋白、骨髓细胞密度以及肝脏总巯基和游离巯基含量出现统计学上的显著下降。在第16天时白细胞计数和脾脏重量增加。当小鼠接受相同总剂量2毫克/千克，分为每天三次腹腔注射0.67毫克/千克反，反-己二烯二醛，持续10天和16天时，观察到类似但程度小得多的效应。这种α，β-不饱和醛是小鼠体内一种强效的骨髓毒素。
