France Anne Marie, Hallmark Camden J, Panneer Nivedha, Billock Rachael, Russell Olivia O, Plaster Mary, Alberti Jessica, Nuthan Fathima, Saduvala Neeraja, Philpott David, Ocfemia M Cheryl Bañez, Cope Scott, Hernandez Angela L, Pond Sergei L Kosakovsky, Wertheim Joel O, Weaver Steven, Khader Saja, Johnson Kevin, Oster Alexandra M
Emerg Infect Dis. 2025 May;31(13):80-88. doi: 10.3201/eid3113.241143.
Detecting and responding to clusters of rapid HIV transmission is a core HIV prevention strategy in the United States, guiding public health interventions and identifying gaps in prevention and care services. In 2016, the Centers for Disease Control and Prevention (CDC) initiated molecular cluster detection using data from 27 jurisdictions. During 2016-2023, CDC expanded sequence reporting nationwide and deployed Secure HIV-TRACE, an application supporting health department (HD) molecular cluster detection. CDC conducts molecular cluster detection quarterly; state and local HDs analyze local data monthly. HDs began routinely reporting clusters to CDC by using cluster report forms in 2020. During 2018-2023, CDC identified 404 molecular clusters of rapid HIV transmission; 325 (80%) involved multiple jurisdictions. During 2020-2023, HDs reported 298 molecular clusters to CDC; 249 were first detected by HDs. Expanding molecular cluster detection has provided a foundation for improving service delivery to networks experiencing rapid HIV transmission.
检测和应对艾滋病毒快速传播集群是美国一项核心的艾滋病毒预防策略，它指导着公共卫生干预措施，并找出预防和护理服务中的差距。2016年，疾病控制与预防中心（CDC）利用来自27个司法管辖区的数据启动了分子集群检测。在2016年至2023年期间，CDC在全国范围内扩大了序列报告，并部署了Secure HIV-TRACE，这是一款支持卫生部门（HD）进行分子集群检测的应用程序。CDC每季度进行一次分子集群检测；州和地方卫生部门每月分析本地数据。卫生部门自2020年起开始使用集群报告表向CDC定期报告集群情况。在2018年至2023年期间，CDC识别出404个艾滋病毒快速传播分子集群；其中325个（80%）涉及多个司法管辖区。在2020年至2023年期间，卫生部门向CDC报告了298个分子集群；其中249个是由卫生部门首次检测到的。扩大分子集群检测为改善向经历艾滋病毒快速传播的网络提供服务奠定了基础。
