High Life's Essential 8 Score Reduces the Risk of Aortic Valve Calcification.

AIM

This study aims to investigate the association between Life's Essential 8 (LE8) and Aortic Valve Calcification (AVC) and to evaluate whether a high LE8 score can effectively reduce the risk of AVC.

METHODS

This study included 30,561 participants from the Kailuan cohort who completed the Kailuan health examination and underwent ultrasound evaluations. A multifactorial logistic regression analysis was used to assess the relationship between LE8 score and AVC, along with subgroup analyses and an analysis of the impact of each component of LE8 on AVC.

RESULTS

Among the 30,561 participants, 3,717(12.16%) cases of AVC were detected, with a detection rate of 12.16%. The detection rate of AVC significantly decreased with increased LE8 (P<0.001). The risk of AVC was reduced by 34% in the moderate Cardiovascular Health (CVH) group (OR=0.66, 95% CI 0.60-0.72) and by 63% in the high CVH group (OR=0.37, 95% CI 0.27-0.50). For each standard deviation increase in the LE8 score, the risk of AVC decreased by 23% (OR=0.77, 95% CI 0.74-0.80). Analysis of the individual components of LE8 revealed that diet, exercise, body mass index, blood lipids, blood glucose, and blood pressure were all associated with the reduced risk of AVC. In contrast, no impact of sleep and smoking on AVC risk was observed.

CONCLUSIONS

The study indicates that a high LE8 score was associated with low AVC risk, suggesting a new prevention strategy through healthy behaviors and lifestyle changes.