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在直接伸手够物任务中人类杏仁核的β波段功率调制。

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task.

作者信息

Cavaleri Jonathon, Sundaram Shivani, Del Campo-Vera Roberto Martin, Shao Xiecheng, Chung Ryan S, Parra Miguel, Swarup Adith, Zhang Selena, Kammen Alexandra, Gogia Angad, Mason Xenos, McGinn Ryan, Heck Christi, Liu Charles Y, Kellis Spencer S, Lee Brian

机构信息

Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.

Department of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.

出版信息

Neurosci Res. 2025 Jul;216:104906. doi: 10.1016/j.neures.2025.05.001. Epub 2025 May 11.


DOI:10.1016/j.neures.2025.05.001
PMID:40360082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12288141/
Abstract

The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13-30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.

摘要

人类杏仁核主要因其在处理情绪和恐惧反应中的作用而闻名,但最新证据表明该结构在运动处理中也发挥作用。我们实验室之前利用一项手臂伸展任务,观察到海马体中显著的β波段(13 - 30赫兹)调制。基于这些结果,我们试图通过立体脑电图(SEEG)深度电极植入杏仁核以进行癫痫定位,来表征β波段调制在参与者运动执行过程中杏仁核的作用。我们发现,与注视(基线)阶段相比,在手臂伸展任务的反应(运动执行)阶段,13名参与者中有9名(69.2%)杏仁核中的β波段功率降低。二次分析表明,同侧和对侧植入电极之间的β波段调制在统计学上没有显著差异,但男性和女性参与者之间存在细微差异。直接伸手任务反应阶段杏仁核中β波段功率的降低与我们之前在海马体中的发现一致。我们的研究首次报告了运动处理过程中杏仁核的β波段调制,为进一步研究杏仁核在运动控制中的作用奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/5bee2186f6cf/nihms-2089037-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/cd1b2c65d54f/nihms-2089037-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/f7cf47c9f63a/nihms-2089037-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/1564fbb50519/nihms-2089037-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/5bee2186f6cf/nihms-2089037-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/cd1b2c65d54f/nihms-2089037-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/f7cf47c9f63a/nihms-2089037-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/1564fbb50519/nihms-2089037-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ea/12288141/5bee2186f6cf/nihms-2089037-f0004.jpg

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本文引用的文献

[1]
Beta-band power is an index of multisensory weighting during self-motion perception.

Neuroimage Rep. 2022-5-28

[2]
Beta-band power modulation in the human amygdala differentiates between go/no-go responses in an arm-reaching task.

J Neural Eng. 2024-7-16

[3]
Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state.

Neuron. 2024-4-3

[4]
Driving drowsiness detection using spectral signatures of EEG-based neurophysiology.

Front Physiol. 2023-3-30

[5]
EEG Beta functional connectivity decrease in the left amygdala correlates with the affective pain in fibromyalgia: A pilot study.

PLoS One. 2023

[6]
Decision-making in stereotactic epilepsy surgery.

Epilepsia. 2022-11

[7]
Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus.

Neuromodulation. 2022-2

[8]
Gamma-band modulation in the human amygdala during reaching movements.

Neurosurg Focus. 2020-7

[9]
The Motor Cortex Has Independent Representations for Ipsilateral and Contralateral Arm Movements But Correlated Representations for Grasping.

Cereb Cortex. 2020-9-3

[10]
Beta-band power modulation in the human hippocampus during a reaching task.

J Neural Eng. 2020-6-12

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