Maksten Eva Futtrup, Jensen Jonas Faartoft, Thomsen Gitte, Zenas Ditte Rechter, Jørgensen Maren Poulsgaard, Udby Lene, Fonager Kirsten, Severinsen Marianne Tang
Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark.
Cancers (Basel). 2025 May 7;17(9):1585. doi: 10.3390/cancers17091585.
: Patients with chronic myeloid leukemia (CML) have a long life expectancy due to modern treatment. However, treatment may have adverse effects that hamper work ability. : Patients aged 25-60 years diagnosed in 2002-2020 were included in this nationwide matched cohort study examining work ability from diagnosis (index date), including the need for permanent disability compensation (flexible job or disability pension). Each patient was matched 1:5 on sex, birth year, and level of comorbidity with citizens from the general Danish population without CML. The risks of requiring flexible job and disability pension were calculated by cause-specific hazard ratios (HRs) using Cox proportional hazards regression, and the Aalen-Johansen estimator was used to determine cumulative risks. : A total of 489 patients with CML and 2445 matched comparators were included. The median age was 46 years, and males comprised 59.5% of the cohort. Matched comparators were more likely to work at index date and 1, 3, 5, and 10 years after the index date ( < 0.001). The HRs of requiring both flexible job (HR 8.7 (95% confidence interval (CI): 6.1;12.2, < 0.001)) and disability pension (HR 3.7 (95% CI: 2.8;4.9, < 0.001)) were higher among patients diagnosed with CML compared to matched comparators. The cumulative risk of requiring flexible job and disability pension also increased in patients with CML compared to matched comparators ( < 0.001). : Patients with CML have a reduced work ability compared to the general population. More research is needed to determine the cause of their loss of ability to work.
由于现代治疗方法，慢性粒细胞白血病（CML）患者的预期寿命较长。然而，治疗可能会产生不利影响，从而妨碍工作能力。在这项全国性匹配队列研究中，纳入了2002年至2020年期间诊断出的25至60岁的患者，该研究从诊断（索引日期）开始检查工作能力，包括对永久残疾补偿（灵活工作或残疾抚恤金）的需求。每位患者在性别、出生年份和合并症水平方面与丹麦普通人群中无CML的公民按1:5进行匹配。使用Cox比例风险回归，通过特定病因风险比（HRs）计算需要灵活工作和残疾抚恤金的风险，并使用Aalen-Johansen估计量来确定累积风险。总共纳入了489例CML患者和2445例匹配的对照者。中位年龄为46岁，男性占队列的59.5%。匹配的对照者在索引日期以及索引日期后1、3、5和10年更有可能工作（P<0.001）。与匹配的对照者相比，诊断为CML的患者需要灵活工作（HR 8.7（95%置信区间（CI）：；12.2，P<0.001））和残疾抚恤金（HR 3.7（95%CI：2.8；4.9，P<0.001））的HRs更高。与匹配的对照者相比，CML患者需要灵活工作和残疾抚恤金的累积风险也增加了（P<0.001）。与普通人群相比，CML患者的工作能力降低。需要更多的研究来确定他们工作能力丧失的原因。
