Cheładze Przemysław, Fułek Michał, Fułek Katarzyna, Poręba Rafał, Gać Paweł
Centre for Diagnostic Imaging, 4th Military Hospital, 50-981 Wroclaw, Poland.
Department of Diabetology, Hypertension and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Diagnostics (Basel). 2025 Apr 24;15(9):1075. doi: 10.3390/diagnostics15091075.
: Recent advancements in cardiovascular imaging have opened new avenues for integrating novel biomarkers into risk assessment models, enhancing their predictive accuracy. One such emerging biomarker is the left atrioventricular coupling index (LACI). The study aims to evaluate the relationship between the SCORE (Systematic Coronary Risk Evaluation) and LACI derived from cardiac computed tomography (CCT). : This study included 137 participants (56.09 ± 7.64 years). Cardiovascular risk was assessed using the SCORE system. CCT was performed using the standard coronary computed tomography angiography protocol. LACI was calculated as the ratio of left atrial end-diastolic volume (LA EDV) to left ventricular end-diastolic volume (LV EDV), expressed as a percentage. : The subgroup with SCORE ≥5% had higher LACI than the subgroup with SCORE < 5%. Similarly, the subgroup with SCORE ≥10% had higher LACI than the subgroup with SCORE < 10%. LACI demonstrated a significant positive correlation with the SCORE (r = 0.29, = 0.01). Prediction analysis showed that LACI ≥ 53.34% as a predictor of SCORE ≥ 10% had the highest accuracy of 78.1%, with a high sensitivity of 79.8% and a moderate specificity of 61.5%. High specificity (80.6%) is characterized by LACI ≥ 29.52% as a predictor of SCORE ≥ 5. : LACI is a novel and significant biomarker associated with cardiovascular risk, as reflected by its relationship with the SCORE system.
心血管成像领域的最新进展为将新型生物标志物整合到风险评估模型中开辟了新途径，提高了其预测准确性。一种新兴的生物标志物就是左房室耦合指数（LACI）。本研究旨在评估系统性冠状动脉风险评估（SCORE）与源自心脏计算机断层扫描（CCT）的LACI之间的关系。
本研究纳入了137名参与者（年龄56.09±7.64岁）。使用SCORE系统评估心血管风险。采用标准冠状动脉计算机断层扫描血管造影协议进行CCT检查。LACI计算为左心房舒张末期容积（LA EDV）与左心室舒张末期容积（LV EDV）的比值，以百分比表示。
SCORE≥5%的亚组LACI高于SCORE<5%的亚组。同样，SCORE≥10%的亚组LACI高于SCORE<10%的亚组。LACI与SCORE呈显著正相关（r = 0.29，P = 0.01）。预测分析显示，LACI≥53.34%作为SCORE≥10%的预测指标，准确率最高，为78.1%，敏感性高，为79.8%，特异性中等，为61.5%。以LACI≥29.52%作为SCORE≥5%的预测指标，特异性高（80.6%）。
LACI是一种与心血管风险相关的新型重要生物标志物，这一点从它与SCORE系统的关系中得到了体现。
