Chatzikostopoulos Athanasios, Moraitou Despina, Papaliagkas Vasileios, Tsolaki Magda
Laboratory of Psychology, Department of Cognition, Brain and Behavior, School of Psychology, Faculty of Philosophy, Aristotle University of Thessaloniki (AUTh), 54124 Thessaloniki, Greece.
Laboratory of Neurodegenerative Diseases, Center of Interdisciplinary Research and Innovation (CIRI-AUTH), Balcan Center, Buildings A & B, 57001 Thessaloniki, Greece.
Diagnostics (Basel). 2025 Apr 24;15(9):1082. doi: 10.3390/diagnostics15091082.
Symptoms (NPS) in Alzheimer's disease (AD) have multiple effects in daily living, not only for the patients but for their caregivers too. The present systematic review was performed in order to identify if biomarkers, cognitive functions, and personality traits can be considered as important factors for the development and maintenance of these symptoms. To achieve that, the existing literature spanning the period from 2018 to 2024 was critically analyzed. To be included in the review, a study had to investigate any of the factors mentioned above. In total, 182 articles were assessed for eligibility, and 50 met the inclusion criteria. Most of the studies were focused on the role of biomarkers and found that amyloid β, tau and phospho-tau protein are closely related to the incidence and the severity of NPS. In fewer studies, cognitive function and personality traits were also associated with NPS. In conclusion, biomarkers, cognitive function and personality traits are associated with NPS, but the underlying mechanisms, still, mostly remain unknown.
阿尔茨海默病（AD）中的症状（神经精神症状，NPS）对日常生活有多种影响，不仅对患者如此，对其照料者也是如此。进行本系统综述是为了确定生物标志物、认知功能和人格特质是否可被视为这些症状发生和维持的重要因素。为实现这一目的，对2018年至2024年期间的现有文献进行了批判性分析。要纳入该综述，一项研究必须调查上述任何一个因素。总共评估了182篇文章的 eligibility，其中50篇符合纳入标准。大多数研究聚焦于生物标志物的作用，发现淀粉样β蛋白、tau蛋白和磷酸化tau蛋白与神经精神症状的发生率和严重程度密切相关。在较少的研究中，认知功能和人格特质也与神经精神症状有关。总之，生物标志物、认知功能和人格特质与神经精神症状有关，但潜在机制大多仍不明。
