Przewodowska Dominika, Alster Piotr, Madetko-Alster Natalia
Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.
Int J Mol Sci. 2025 Apr 22;26(9):3928. doi: 10.3390/ijms26093928.
The role of the intestinal microbiota and its influence on neurodegenerative disorders has recently been extensively explored, especially in the context of Parkinson's disease (PD). In particular, its role in immunomodulation, impact on inflammation, and participation in the gut-brain axis are under ongoing investigations. Recent studies have revealed new data that could be important for exploring the neurodegeneration mechanisms connected with the gut microbiota, potentially leading to the development of new methods of treatment. In this review, the potential roles of the gut microbiota in future disease-modifying therapies were discussed and the properties of the intestinal microbiota-including its impacts on metabolism and short-chain fatty acids and vitamins-were summarized, with a particular focus on atypical Parkinsonian syndromes. This review focused on a detailed description of the numerous mechanisms through which the microbiota influences neurodegenerative processes. This review explored potentially important connections between the gut microbiota and the evolution and progression of atypical Parkinsonian syndromes. Finally, a description of recently derived results regarding the microbiota alterations in atypical Parkinsonian syndromes in comparison with results previously described in PD was also included.
肠道微生物群的作用及其对神经退行性疾病的影响最近已得到广泛研究，尤其是在帕金森病（PD）的背景下。特别是，其在免疫调节中的作用、对炎症的影响以及在肠-脑轴中的参与情况正在持续研究中。最近的研究揭示了一些新数据，这些数据对于探索与肠道微生物群相关的神经退行性变机制可能很重要，有可能促成新治疗方法的开发。在这篇综述中，讨论了肠道微生物群在未来疾病修饰疗法中的潜在作用，并总结了肠道微生物群的特性，包括其对代谢、短链脂肪酸和维生素的影响，特别关注非典型帕金森综合征。这篇综述着重详细描述了微生物群影响神经退行性过程的众多机制。这篇综述探讨了肠道微生物群与非典型帕金森综合征的演变和进展之间潜在的重要联系。最后，还介绍了与先前在PD中描述的结果相比，非典型帕金森综合征中微生物群改变的最新研究结果。
