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间质性肺疾病的肺移植

Lung transplantation for interstitial lung disease.

作者信息

Ronan Nicola J, Helly Feargal, Murray Michelle A

机构信息

National Heart and Lung Transplant Unit, Mater Misericordiae University Hospital, Dublin, Ireland.

School of Medicine, University College Dublin, Dublin, Ireland.

出版信息

Breathe (Sheff). 2025 May 13;21(2):240169. doi: 10.1183/20734735.0169-2024. eCollection 2025 Apr.

Abstract

Interstitial lung diseases (ILDs) are now the most common indication for lung transplant internationally. Given that many lung transplant candidates with idiopathic pulmonary fibrosis are older, referral to a pulmonary rehabilitation programme is important to help mitigate the adverse outcomes associated with frailty. Despite this increase many patients with ILD who would potentially benefit from lung transplant are either not referred or referred too late. Particularly relevant in ILD which may have prominent extra-pulmonary manifestations is a multidisciplinary assessment of comorbidities which may impact on post lung transplant outcomes. Particular challenges in lung transplant for ILD are increasing age, comorbidities, donor lung sizing and the risk-benefit balance of single bilateral lung transplant. Evidence is continuing to evolve for lung transplant in rarer ILDs, including surfactant protein associated ILD and TERT mutations. Unfortunately, the number of potential lung transplant recipients exceeds available donor organs and some patients will die without transplant. Palliative care is an important aspect of managing patients on an active lung transplant list to help optimise physical and psychological symptoms associated with uncertainty on an active lung transplant list.

摘要

间质性肺疾病(ILDs)目前是国际上肺移植最常见的适应症。鉴于许多患有特发性肺纤维化的肺移植候选者年龄较大,转介至肺康复计划对于帮助减轻与虚弱相关的不良后果很重要。尽管有这种增长,但许多可能从肺移植中受益的ILD患者要么未被转介,要么转介得太晚。在可能有突出肺外表现的ILD中,对可能影响肺移植后结果的合并症进行多学科评估尤为重要。ILD肺移植的特殊挑战包括年龄增长、合并症、供体肺大小匹配以及单肺移植与双肺移植的风险效益平衡。对于包括表面活性蛋白相关ILD和TERT突变在内的罕见ILD,肺移植的证据仍在不断发展。不幸的是,潜在的肺移植受者数量超过了可用的供体器官,一些患者将在没有移植的情况下死亡。姑息治疗是管理处于肺移植等待名单上患者的一个重要方面,有助于优化与处于肺移植等待名单上的不确定性相关的身体和心理症状。

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本文引用的文献

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