Imanishi H, Nakai T, Abe T, Takino T
Acta Vitaminol Enzymol. 1985;7(1-2):71-5.
The mechanism of the phenylhydrazine induced oxidative hemolysis was studied on the point of role of the free radical scavengers in rats. Phenylhydrazine resulted in the degradation of hemoglobin and the lipid peroxidation of the erythrocyte membrane. Otherwise, the elevation of coenzyme Q9, endogenous CoQ in rats, levels in plasma was observed against the phenylhydrazine induced oxidative stress. Supplementation of coenzyme Q10, exogenous CoQ in rats, inhibited the phenylhydrazine induced hemolysis according to the suppression of both the degradation of hemoglobin and the lipid peroxidation of the erythrocyte membrane. These results suggest that free radical scavengers such as coenzyme Q9 and coenzyme Q10 have important roles on the phenylhydrazine induced hemolysis in rats.
从自由基清除剂在大鼠体内的作用角度，研究了苯肼诱导氧化溶血的机制。苯肼导致血红蛋白降解以及红细胞膜脂质过氧化。此外，观察到大鼠血浆中内源性辅酶Q9（大鼠体内的辅酶Q）水平因苯肼诱导的氧化应激而升高。补充大鼠体内外源性辅酶Q10可抑制苯肼诱导的溶血，这是通过抑制血红蛋白降解和红细胞膜脂质过氧化实现的。这些结果表明，辅酶Q9和辅酶Q10等自由基清除剂在苯肼诱导的大鼠溶血过程中具有重要作用。
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