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近乎溺水的昏迷儿童的预后变量。

Prognostic variables in nearly drowned, comatose children.

作者信息

Nussbaum E

出版信息

Am J Dis Child. 1985 Oct;139(10):1058-9. doi: 10.1001/archpedi.1985.02140120104038.

DOI:10.1001/archpedi.1985.02140120104038
PMID:4036894
Abstract

Prognostic variables were evaluated in 51 nearly drowned, comatose children, and they included values for age, estimated submersion time, initial arterial pH and core temperature, mean intracranial pressure (ICP), and mean cerebral perfusion pressure (CPP); the latter two values were obtained during the first 24 hours. There were 33 survivors (19 with intact neurologic survival and 14 with brain damage) and 18 deaths. Estimated submersion time and mean ICP and mean CPP determined survival but could not predict the neurologic outcome (intact survival or brain damage). Age, arterial pH, and core temperature were not useful variables in predicting outcome. This study discourages the use of these unreliable variables in predicting survival in nearly drowned, comatose victims and, in addition, cautions against the use of mean ICP, mean CPP, and submersion time as predictors of neurologic outcome. Since mean ICP and mean CPP measurements are reliable in predicting survival but not neurologic outcome, major efforts should be undertaken to explore neurophysiologic and metabolic prognostic factors that may either discourage or mandate early institution of aggressive cerebral resuscitative measures in nearly drowned victims.

摘要

对51名近乎溺水的昏迷儿童的预后变量进行了评估,这些变量包括年龄、估计的淹没时间、初始动脉pH值和核心温度、平均颅内压(ICP)以及平均脑灌注压(CPP);后两个值是在最初24小时内获得的。有33名幸存者(19名神经功能完整存活,14名有脑损伤)和18例死亡。估计的淹没时间以及平均ICP和平均CPP决定了存活情况,但无法预测神经学结果(完整存活或脑损伤)。年龄、动脉pH值和核心温度在预测结果方面不是有用的变量。这项研究不鼓励在预测近乎溺水的昏迷受害者的存活情况时使用这些不可靠的变量,此外,还告诫不要将平均ICP、平均CPP和淹没时间用作神经学结果的预测指标。由于平均ICP和平均CPP测量在预测存活情况方面可靠,但在预测神经学结果方面不可靠,因此应大力探索神经生理学和代谢预后因素,这些因素可能会促使或要求对近乎溺水的受害者尽早采取积极的脑复苏措施。

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引用本文的文献

1
Brain resuscitation in the drowning victim.溺水者的脑复苏。
Neurocrit Care. 2012 Dec;17(3):441-67. doi: 10.1007/s12028-012-9747-4.
2
Neurological intensive care in children.儿童神经重症监护
Intensive Care Med. 1993;19(5):243-50. doi: 10.1007/BF01690543.
3
Intracranial pressure monitoring following hypoxic-ischaemic cerebral insults.缺氧缺血性脑损伤后的颅内压监测
Childs Nerv Syst. 1989 Oct;5(5):280. doi: 10.1007/BF00274514.
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The cerebral function analysing monitor in paediatric medical intensive care: applications and limitations.小儿重症监护中的脑功能分析监测仪:应用与局限性
Intensive Care Med. 1990;16(1):60-8. doi: 10.1007/BF01706327.