Nussbaum E
Am J Dis Child. 1985 Oct;139(10):1058-9. doi: 10.1001/archpedi.1985.02140120104038.
Prognostic variables were evaluated in 51 nearly drowned, comatose children, and they included values for age, estimated submersion time, initial arterial pH and core temperature, mean intracranial pressure (ICP), and mean cerebral perfusion pressure (CPP); the latter two values were obtained during the first 24 hours. There were 33 survivors (19 with intact neurologic survival and 14 with brain damage) and 18 deaths. Estimated submersion time and mean ICP and mean CPP determined survival but could not predict the neurologic outcome (intact survival or brain damage). Age, arterial pH, and core temperature were not useful variables in predicting outcome. This study discourages the use of these unreliable variables in predicting survival in nearly drowned, comatose victims and, in addition, cautions against the use of mean ICP, mean CPP, and submersion time as predictors of neurologic outcome. Since mean ICP and mean CPP measurements are reliable in predicting survival but not neurologic outcome, major efforts should be undertaken to explore neurophysiologic and metabolic prognostic factors that may either discourage or mandate early institution of aggressive cerebral resuscitative measures in nearly drowned victims.
对51名近乎溺水的昏迷儿童的预后变量进行了评估,这些变量包括年龄、估计的淹没时间、初始动脉pH值和核心温度、平均颅内压(ICP)以及平均脑灌注压(CPP);后两个值是在最初24小时内获得的。有33名幸存者(19名神经功能完整存活,14名有脑损伤)和18例死亡。估计的淹没时间以及平均ICP和平均CPP决定了存活情况,但无法预测神经学结果(完整存活或脑损伤)。年龄、动脉pH值和核心温度在预测结果方面不是有用的变量。这项研究不鼓励在预测近乎溺水的昏迷受害者的存活情况时使用这些不可靠的变量,此外,还告诫不要将平均ICP、平均CPP和淹没时间用作神经学结果的预测指标。由于平均ICP和平均CPP测量在预测存活情况方面可靠,但在预测神经学结果方面不可靠,因此应大力探索神经生理学和代谢预后因素,这些因素可能会促使或要求对近乎溺水的受害者尽早采取积极的脑复苏措施。