Sun Jiazheng, Zhou Sirui, Sun Yalu, Zeng Yulan
Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Affiliated Hospital of Jining Medical University, Jining, China.
Front Med (Lausanne). 2025 Apr 30;12:1541104. doi: 10.3389/fmed.2025.1541104. eCollection 2025.
One of the leading causes of cancer-related mortality globally is non-small cell lung cancer (NSCLC). It has become a significant public health concern due to its rising incidence rate and fatality. Tumor-associated macrophage (TAM) is important in the tumor microenvironment (TME) of NSCLC because they have an impact on the development, metastasis, and incidence of tumors. As a crucial element of the TME, TAM contributes to tumor immune evasion, facilitates tumor proliferation and metastasis, and modulates tumor angiogenesis, immunosuppression, and treatment resistance through the secretion of diverse cytokines, chemokines, and growth factors. Consequently, TAM assumes a multifaceted and intricate function in the onset, progression, and therapeutic response of NSCLC, serving as a crucial focal point for comprehending the tumor microenvironment and formulating novel therapeutic methods. The study aims to review the biological properties and potential processes of TAM in NSCLC, investigate its involvement in the clinical of NSCLC patients, and discuss its potential as a therapeutic target.
全球与癌症相关的死亡的主要原因之一是非小细胞肺癌（NSCLC）。由于其发病率和死亡率不断上升，它已成为一个重大的公共卫生问题。肿瘤相关巨噬细胞（TAM）在NSCLC的肿瘤微环境（TME）中很重要，因为它们对肿瘤的发展、转移和发生有影响。作为TME的关键要素，TAM通过分泌多种细胞因子、趋化因子和生长因子，促进肿瘤免疫逃逸，推动肿瘤增殖和转移，并调节肿瘤血管生成、免疫抑制和治疗抗性。因此，TAM在NSCLC的发生、发展和治疗反应中发挥着多方面且复杂的作用，是理解肿瘤微环境和制定新治疗方法的关键焦点。该研究旨在综述TAM在NSCLC中的生物学特性和潜在过程，研究其在NSCLC患者临床中的参与情况，并讨论其作为治疗靶点的潜力。
