Niu Fugui, Long Gaoxin, Zhang Jian, Yu Jun, Ji Sheng-Jian
Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Aging Cell. 2025 May 15;24(7):e70107. doi: 10.1111/acel.70107.
Aging-related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the mA reader YTHDF2 is a negative regulator for dendrite development and protection of retinal ganglion cells (RGC) in mice. Here, we further show that conditional ablation of Ythdf2 protects the retina from RGC dendrite shrinking and vision loss in aged mice. Additionally, we identify Hspa12a and Islr2 as the potential YTHDF2 target mRNAs mediating these effects. Together, our results indicate that the mA reader YTHDF2 regulates retinal degeneration caused by aging, which might provide important therapeutic potential for developing new treatment approaches against aging-related vision loss.
与衰老相关的视网膜变性和视力丧失严重影响着全球老年人。此前，我们发现m⁶A阅读器YTHDF2是小鼠中视网膜神经节细胞（RGC）树突发育和保护的负调节因子。在此，我们进一步表明，条件性敲除Ythdf2可保护老年小鼠的视网膜免受RGC树突萎缩和视力丧失的影响。此外，我们确定Hspa12a和Islr2是介导这些效应的潜在YTHDF2靶标mRNA。总之，我们的结果表明，m⁶A阅读器YTHDF2调节衰老引起的视网膜变性，这可能为开发针对与衰老相关的视力丧失的新治疗方法提供重要的治疗潜力。
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