Ou Feiya, Murphy Kenneth M
Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
J Exp Med. 2025 Aug 4;222(8). doi: 10.1084/jem.20250760. Epub 2025 May 15.
Recent publications have demonstrated that antigen-presenting cells (APCs) targeted by Rorc-cre (also known as RORγt-cre) are required for the induction of peripheral regulatory T (pTreg) cells in response to commensal and dietary antigens. In this issue of JEM, Sun et al. (https://doi.org/10.1084/jem.20250573) provide key insights into the identity of these cells, revealing that Rorc-cre-traced APCs include group 3 innate lymphoid cells (ILC3s), dendritic cells (DCs), and extrathymic AIRE-expressing cells (eTACs). Their work highlights eTACs as critical for inducing RORγt+ pTregs specific to food antigens, while implicating DCs in the generation of RORγt- pTregs.
最近的出版物表明，Rorc-cre（也称为RORγt-cre）靶向的抗原呈递细胞（APC）是诱导外周调节性T（pTreg）细胞以响应共生和饮食抗原所必需的。在本期《细胞与分子免疫学杂志》中，孙等人（https://doi.org/10.1084/jem.20250573）对这些细胞的身份提供了关键见解，揭示了Rorc-cre追踪的APC包括3型固有淋巴细胞（ILC3）、树突状细胞（DC）和胸腺外表达AIRE的细胞（eTAC）。他们的工作强调eTAC对于诱导食物抗原特异性的RORγt+ pTreg至关重要，同时表明DC参与RORγt- pTreg的产生。
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