Mohamed Shereen A, Elsawy Hanan M, Bazaraa Hafez M, Ghobashy Mohamed H, El Megied Mohamed Abdallah Abd
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Radiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Sci Rep. 2025 May 15;15(1):16946. doi: 10.1038/s41598-025-01205-w.
Muscle wasting occurs early during critical illness. It is associated with poor PICU outcomes. Ultrasonography can detect muscle thickness in critically ill children. Study quadriceps muscle thickness to assess the nutritional status on admission and follow the muscle thickness change throughout the first week of admission in PICU using point-of-care ultrasonography. This cohort study was conducted on 55 critically ill mechanically ventilated children aged between 2 months and 14 years. Serial measurements of quadriceps muscle thickness were done by ultrasound, during the first week of admission. Quadriceps muscle thickness decreased by 16.4% over the 1st week of admission. The muscle wasting was significantly correlated with STRONGkids score, the inability to achieve target caloric requirements during the 1st week of admission, duration of ventilation, PRISM score, and mortality. Point of care ultrasonography is an easy tool for assessing PICU muscle wasting. Loss of muscle mass during the first week of PICU admission is correlated to mortality, thus it can be utilized in predicting PICU outcomes.
肌肉萎缩在危重症早期就会出现。它与儿科重症监护病房(PICU)的不良预后相关。超声检查可检测危重症儿童的肌肉厚度。研究股四头肌厚度以评估入院时的营养状况,并使用床旁超声检查在PICU入院的第一周内跟踪肌肉厚度变化。这项队列研究针对55名年龄在2个月至14岁之间的危重症机械通气儿童进行。在入院的第一周内,通过超声对股四头肌厚度进行连续测量。股四头肌厚度在入院的第一周内下降了16.4%。肌肉萎缩与STRONGkids评分、入院第一周内无法达到目标热量需求、通气时间、PRISM评分和死亡率显著相关。床旁超声检查是评估PICU肌肉萎缩的简便工具。PICU入院第一周内肌肉质量的丧失与死亡率相关,因此可用于预测PICU的预后。