Gao Xizhuang, Shi Lihao, Jing Dehuai, Ma Cuimei, Wang Quanyi, Wang Jiehuan, Zhu Fengqin, Zhao Mengmeng, Chen Yun, Zhou Guangxi
Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, People's Republic of China.
Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
J Inflamm Res. 2025 May 10;18:6123-6131. doi: 10.2147/JIR.S507209. eCollection 2025.
COVID-19 can affect multiple organ systems beyond the respiratory tract, including the gastrointestinal tract, where gastrointestinal symptoms include nausea, vomiting, diarrhea, abdominal pain, and even serious manifestations such as ulcers, perforation, or gastrointestinal bleeding.
We report a case of a 45-year-old male patient with small bowel ulcers caused by chronic COVID-19 infection. Initially presenting with fever and transient unconsciousness, he developed ischemic necrosis and required a mid-thigh amputation. Despite treatment with anti-infection therapy, extracorporeal membrane oxygenation, and continuous renal replacement therapy, he experienced persistent abdominal pain and gastrointestinal bleeding. Imaging and colonoscopy confirmed partial small bowel obstruction and inflammation. After treatment with methylprednisolone and enteral nutrition, his symptoms improved. However, he suffered a gastrointestinal perforation requiring emergency surgery and later underwent a successful stoma reversal. The patient was subsequently discharged with improvement and was discharged with a primary diagnosis of "enterostomal status, perforation of small intestinal ulcer, viral myocarditis, COVID-19 infection, and post right lower extremity amputation". During the past year of follow-up, the patient has not experienced any recurrence of abdominal pain or rectal bleeding.
Although coronavirus pneumonia combined with small bowel ulcers is rare, it requires emergency treatment and has a high mortality rate. This case highlighted the severe gastrointestinal complications induced by COVID-19 infection and the effectiveness of comprehensive management strategies.
新型冠状病毒肺炎(COVID-19)可影响呼吸道以外的多个器官系统,包括胃肠道,胃肠道症状包括恶心、呕吐、腹泻、腹痛,甚至出现溃疡、穿孔或胃肠道出血等严重表现。
我们报告一例由慢性COVID-19感染引起小肠溃疡的45岁男性患者。该患者最初表现为发热和短暂昏迷,随后出现缺血性坏死并需要进行大腿中段截肢。尽管接受了抗感染治疗、体外膜肺氧合和持续肾脏替代治疗,但他仍持续腹痛和胃肠道出血。影像学检查和结肠镜检查证实存在部分小肠梗阻和炎症。经甲泼尼龙和肠内营养治疗后,他的症状有所改善。然而,他出现了胃肠道穿孔,需要进行急诊手术,后来成功进行了造口回纳术。患者随后病情好转出院,出院时的主要诊断为“造口状态、小肠溃疡穿孔、病毒性心肌炎、COVID-19感染、右下肢截肢术后”。在过去一年的随访中,患者未出现腹痛或直肠出血复发。
尽管冠状病毒肺炎合并小肠溃疡较为罕见,但需要紧急治疗且死亡率较高。本病例突出了COVID-19感染引起的严重胃肠道并发症以及综合管理策略的有效性。