Zheng Qifan, Xu Tong, Luo Shiyin, Zhao Jiahui, Ying Yue, Liu Nan, Jiang Aijia, Pan Yaping, Zhang Dongmei
Department of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Department of Oral Mucosiology, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Sci Rep. 2025 May 16;15(1):17062. doi: 10.1038/s41598-025-99742-x.
To investigate the causal relationship between oral infectious diseases and lacunar stroke (LS) and to identify the role of interleukin-1α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reaction protein (CRP) as potential mediators. The meta-analysis incorporating cross-sectional studies was carried out. Additionally, two-sample Mendelian randomization (MR) analysis was performed to explore the associations between genetically predicted oral infectious diseases (including dental caries, periodontitis, and pulp and periapical diseases) and lacunar stroke, utilizing summary-level data from genome-wide association studies (GWAS). This was followed by a mediation analysis to explore the role of IL-1α, IL-6, TNF, and CRP. Meta-analysis suggested that individuals with periodontitis have a 5.16 times higher risk of developing LS compared to those without periodontitis (95%CI 3.68-7.24). Genetically predicted pulp and periapical diseases (Odds ratios [OR]: 1.20, 95% CI 1.03-1.41) and periodontitis (OR: 1.24, 95%CI 1.03-1.49) showed a moderate association with LS. However, the mediation analysis yielded negative results. The evidence derived from both the MR study and the meta-analysis suggested a potential association between periodontitis and LS. These findings indicated that periodontitis might play a role in the development of LS. However, given the limitations inherent in our research, further studies are necessary to validate these conclusions.
研究口腔感染性疾病与腔隙性脑卒（LS）之间的因果关系，并确定白细胞介素-1α（IL-1α）、白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）和C反应蛋白（CRP）作为潜在介质的作用。进行了纳入横断面研究的荟萃分析。此外，利用全基因组关联研究（GWAS）的汇总水平数据，进行了两样本孟德尔随机化（MR）分析，以探讨基因预测的口腔感染性疾病（包括龋齿、牙周炎以及牙髓和根尖周疾病）与腔隙性脑卒之间的关联。随后进行中介分析，以探讨IL-1α、IL-6、TNF和CRP的作用。荟萃分析表明，与没有牙周炎的个体相比，患有牙周炎的个体发生腔隙性脑卒的风险高5.16倍（95%CI 3.68-7.24）。基因预测的牙髓和根尖周疾病（优势比[OR]：1.20，95%CI 1.03-1.41）和牙周炎（OR：1.24，95%CI 1.03-1.49）与腔隙性脑卒呈中度关联。然而，中介分析得出了阴性结果。MR研究和荟萃分析得出的证据均表明牙周炎与腔隙性脑卒之间存在潜在关联。这些发现表明牙周炎可能在腔隙性脑卒的发生中起作用。然而，鉴于我们研究中存在的固有局限性，需要进一步研究来验证这些结论。
