Bator S
Arch Otorhinolaryngol. 1985;242(1):19-25. doi: 10.1007/BF00464401.
In the search for new materials to fill the unilaterally paralysed vocal cord, auto- and allogeneic chondrocytes were isolated from costal cartilage, and were injected into the canine vocal cord. The produced cartilage caused a thickening and shift of the treated cord towards the median line of the glottis. Such changes occurred in all autogeneic transplants, and persisted for the period of observation (up to 6 weeks). In allogeneic transplants, the effect was present after 6 and 12 weeks, but disappeared after 18 weeks. Cartilage produced by the autogeneic chondrocytes persisted at the site of injection without any signs of resorption. In contrast, allogeneic cartilage became surrounded by infiltrating cells and was slowly resorbed to disappear completely between the 12th and 18th weeks of observation. Immunosuppressive treatment of some of the allogeneic chondrocyte recipients reduced the lymphocytic infiltrations occurring, and inhibited the resorption of the reconstructed cord cartilage. Discontinuation of the immunosuppression, however, resulted in subsequent graft loss.
为寻找填充单侧麻痹声带的新材料，从肋软骨中分离出自体和同种异体软骨细胞，并将其注入犬的声带。所形成的软骨导致治疗侧声带增厚并向声门中线移位。这种变化在所有自体移植中均出现，并在观察期（长达6周）内持续存在。在同种异体移植中，6周和12周后有效果，但18周后效果消失。自体软骨细胞产生的软骨在注射部位持续存在，没有任何吸收迹象。相比之下，同种异体软骨被浸润细胞包围，并在观察的第12周和第18周之间缓慢吸收直至完全消失。对一些同种异体软骨细胞接受者进行免疫抑制治疗减少了淋巴细胞浸润的发生，并抑制了重建声带软骨的吸收。然而，停止免疫抑制会导致随后的移植物丢失。
