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探索免疫因素与软骨肉瘤之间的因果关系：一项孟德尔随机化研究。

Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study.

作者信息

Xu Taichuan, Xiao Wentao, Li Wenjie, Xu Xianfa, Zhang Haiwen, Zhang Xian

机构信息

Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China.

Department of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, 214072, Jiangsu, China.

出版信息

Discov Oncol. 2025 May 18;16(1):801. doi: 10.1007/s12672-025-02654-5.

DOI:10.1007/s12672-025-02654-5

PMID:40382743

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12086138/

Abstract

BACKGROUND

Previous studies have investigated the potential role of immune factors in chondrosarcoma (CHS). However, the causal relationship is unknown.

METHODS

A two-sample Mendelian randomization (MR) was used to explore potential correlations between 731 immunocyte phenotypes, 91 inflammatory proteins, and CHS. The data were derived from published summary statistics of genome-wide association studies. Inverse-variance weighted was employed as the primary method. Furthermore, a range of analytical methods, including MR-Egger, weighted mode, and weighted median was used to enhance the robustness of the results. A two-step MR was used to assess the mediating effects of inflammatory proteins. Subsequently, sensitivity and MR Steiger directionality tests were performed.

RESULTS

MR analyses showed that 12 immunocyte phenotypes were positively correlated with CHS (P < 0.05, OR > 1), and 11 immunocyte phenotypes were negatively correlated with CHS (P < 0.05, OR < 1). Five inflammatory proteins were positively associated with CHS (P < 0.05, OR > 1). No heterogeneous or horizontal pleiotropy was found. The MR Steiger analysis found no statistically significant evidence of reverse causation. Mediation analysis did not identify any potential mediating effects.

CONCLUSION

Our study underscores the pivotal role of immune factors in CHS and offers insights that can inform future research.

摘要

背景

既往研究已探讨免疫因子在软骨肉瘤（CHS）中的潜在作用。然而，因果关系尚不清楚。

方法

采用两样本孟德尔随机化（MR）方法，探讨731种免疫细胞表型、91种炎症蛋白与CHS之间的潜在相关性。数据来源于已发表的全基因组关联研究的汇总统计数据。采用逆方差加权作为主要方法。此外，还使用了一系列分析方法，包括MR-Egger、加权模式和加权中位数，以增强结果的稳健性。采用两步MR法评估炎症蛋白的中介作用。随后，进行了敏感性和MR Steiger方向性检验。

结果

MR分析显示，12种免疫细胞表型与CHS呈正相关（P<0.05，OR>1），11种免疫细胞表型与CHS呈负相关（P<0.05，OR<1）。5种炎症蛋白与CHS呈正相关（P<0.05，OR>1）。未发现异质性或水平多效性。MR Steiger分析未发现反向因果关系的统计学显著证据。中介分析未发现任何潜在的中介作用。