Sun Yaocheng, Shen Ying, Yan Yongmin, Luo Wei, Liu Chuanlei, Tang Jianjun
Department of General Surgery, The Wujin Clinical College of Xuzhou Medical University Changzhou 213017, Jiangsu, China.
Department of General Surgery, Wujin Hospital Affiliated with Jiangsu University Changzhou 213017, Jiangsu, China.
Am J Transl Res. 2025 Apr 15;17(4):2527-2540. doi: 10.62347/ZTGP5030. eCollection 2025.
Cancer cells exhibit altered metabolic profiles. Glutaminase 1 (), a key enzyme in cancer cells, promoting glutamine catabolism to glutamate and ammonia, is strongly associated with various human malignancies.
promotes lipid accumulation and cell proliferation by upregulating the expression of sterol regulatory element-binding protein 1 () and SREBP cleavage-activating protein (). Mechanistically, promotes lipid metabolism in HCC cells through the activation of the pathway.
's role in lipid metabolism in hepatocellular carcinoma (HCC) remains unexplored. Our findings indicate that is not only significantly overexpressed in HCC but also negatively correlates with clinical prognosis. Further investigation revealed that drives lipid accumulation and de novo fatty acid synthesis in HCC.
Our study suggests that mediates to drive lipid metabolism in HCC via the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 () signaling pathway, thus we present as a potential biomarker and therapeutic target for HCC.
癌细胞表现出代谢谱的改变。谷氨酰胺酶1（）是癌细胞中的一种关键酶，可促进谷氨酰胺分解为谷氨酸和氨，与多种人类恶性肿瘤密切相关。
通过上调固醇调节元件结合蛋白1（）和SREBP裂解激活蛋白（）的表达促进脂质积累和细胞增殖。机制上，通过激活途径促进肝癌细胞的脂质代谢。
在肝细胞癌（HCC）脂质代谢中的作用仍未被探索。我们的研究结果表明，不仅在肝癌中显著过表达，而且与临床预后呈负相关。进一步研究发现，在肝癌中驱动脂质积累和从头脂肪酸合成。
我们的研究表明，通过磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素复合物1（）信号通路介导驱动肝癌中的脂质代谢，因此我们提出作为肝癌的潜在生物标志物和治疗靶点。
