将用于治疗阿尔茨海默病的药物——全身性胆碱酯酶抑制剂——重新用于治疗干眼症、青光眼和年龄相关性黄斑变性。 - Suppr

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Repurposing Alzheimer's disease medications-systemic cholinesterase inhibitors-for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.

作者信息

Rajagopal Shilpa, Ahuja Pranati, Quach Valerie, Luong Cody, Raji Mukaila A

机构信息

John Sealy School of Medicine, UTMB, 301 University Boulevard, Galveston, TX 77555, USA.

Department of Ophthalmology, UTMB, Galveston, TX, USA.

出版信息

Ther Adv Ophthalmol. 2025 May 16;17:25158414251341022. doi: 10.1177/25158414251341022. eCollection 2025 Jan-Dec.

DOI:10.1177/25158414251341022

PMID:40385500

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12084700/

Abstract

摘要

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本文引用的文献

Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration.

JAMA Ophthalmol. 2024 Feb 1;142(2):108-114. doi: 10.1001/jamaophthalmol.2023.6014.

The Association Between Eye Disease and Incidence of Dementia: Systematic Review and Meta-Analysis.

J Am Med Dir Assoc. 2023 Sep;24(9):1363-1373.e6. doi: 10.1016/j.jamda.2023.06.025. Epub 2023 Jul 29.

Cureus. 2022 Sep 26;14(9):e29583. doi: 10.7759/cureus.29583. eCollection 2022 Sep.

Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US.

JAMA Neurol. 2022 Jun 1;79(6):623-626. doi: 10.1001/jamaneurol.2022.0723.

Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization.

Aging Cell. 2022 Apr;21(4):e13596. doi: 10.1111/acel.13596. Epub 2022 Mar 27.

Effects of Glaucoma Medication on Dry Eye Syndrome and Quality of Life in Patients with Glaucoma.

Korean J Ophthalmol. 2021 Dec;35(6):467-475. doi: 10.3341/kjo.2021.0068. Epub 2021 Oct 12.

Aged Mice Devoid of the M Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease.

Int J Mol Sci. 2021 Jun 7;22(11):6133. doi: 10.3390/ijms22116133.

Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.

Int J Mol Sci. 2021 May 8;22(9):4989. doi: 10.3390/ijms22094989.

The Role of Inflammation in Age-Related Macular Degeneration.

Int J Biol Sci. 2020 Sep 23;16(15):2989-3001. doi: 10.7150/ijbs.49890. eCollection 2020.

Retinal Degeneration and Alzheimer's Disease: An Evolving Link.

Int J Mol Sci. 2020 Oct 2;21(19):7290. doi: 10.3390/ijms21197290.

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Repurposing Alzheimer's disease medications-systemic cholinesterase inhibitors-for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.

作者信息

Rajagopal Shilpa, Ahuja Pranati, Quach Valerie, Luong Cody, Raji Mukaila A

机构信息

John Sealy School of Medicine, UTMB, 301 University Boulevard, Galveston, TX 77555, USA.

Department of Ophthalmology, UTMB, Galveston, TX, USA.

出版信息

Ther Adv Ophthalmol. 2025 May 16;17:25158414251341022. doi: 10.1177/25158414251341022. eCollection 2025 Jan-Dec.

DOI:10.1177/25158414251341022

PMID:40385500

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12084700/

Abstract

摘要

相似文献

Repurposing Alzheimer's disease medications-systemic cholinesterase inhibitors-for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.

Ther Adv Ophthalmol. 2025 May 16;17:25158414251341022. doi: 10.1177/25158414251341022. eCollection 2025 Jan-Dec.

Neovascular Age-Related Macular Degeneration and its Association with Alzheimer's Disease.

Curr Aging Sci. 2020;13(2):102-112. doi: 10.2174/1874609813666200129161833.

Neuropharmacology. 2015 May;92:158-69. doi: 10.1016/j.neuropharm.2014.12.038. Epub 2015 Jan 26.

Glaucoma Tube Outcomes with and without Anti-VEGF in Patients with Age-related Macular Degeneration.

Ophthalmol Glaucoma. 2024 May-Jun;7(3):260-270. doi: 10.1016/j.ogla.2024.01.002. Epub 2024 Jan 22.

SYSTEMIC MEDICATION USE AND THE INCIDENCE AND GROWTH OF GEOGRAPHIC ATROPHY IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS.

Retina. 2021 Jul 1;41(7):1455-1462. doi: 10.1097/IAE.0000000000003075.

[Gerontological aspects of eye diseases].

Vestn Oftalmol. 2022;138(5. Vyp. 2):227-233. doi: 10.17116/oftalma2022138052227.

Diabetic Patients With Rosacea Increase the Risks of Diabetic Macular Edema, Dry Eye Disease, Glaucoma, and Cataract.

Asia Pac J Ophthalmol (Phila). 2022 Nov 1;11(6):505-513. doi: 10.1097/APO.0000000000000571.

Risk of antipsychotic drug use in patients with Alzheimer's disease treated with rivastigmine.

Drugs Aging. 2004;21(6):395-403. doi: 10.2165/00002512-200421060-00004.

Impact of age-related macular degeneration in patients with glaucoma: understanding the patients' perspective.

Clin Exp Ophthalmol. 2016 Jul;44(5):377-87. doi: 10.1111/ceo.12672. Epub 2016 Jan 26.

microRNA pathological mechanisms between Parkinson's disease, Alzheimer's disease, glaucoma and macular degeneration.

Expert Rev Mol Med. 2023 Jul 20;25:e24. doi: 10.1017/erm.2023.19.

本文引用的文献

Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration.

JAMA Ophthalmol. 2024 Feb 1;142(2):108-114. doi: 10.1001/jamaophthalmol.2023.6014.

The Association Between Eye Disease and Incidence of Dementia: Systematic Review and Meta-Analysis.

J Am Med Dir Assoc. 2023 Sep;24(9):1363-1373.e6. doi: 10.1016/j.jamda.2023.06.025. Epub 2023 Jul 29.

Cureus. 2022 Sep 26;14(9):e29583. doi: 10.7759/cureus.29583. eCollection 2022 Sep.

Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US.

JAMA Neurol. 2022 Jun 1;79(6):623-626. doi: 10.1001/jamaneurol.2022.0723.

Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization.

Aging Cell. 2022 Apr;21(4):e13596. doi: 10.1111/acel.13596. Epub 2022 Mar 27.

Effects of Glaucoma Medication on Dry Eye Syndrome and Quality of Life in Patients with Glaucoma.

Korean J Ophthalmol. 2021 Dec;35(6):467-475. doi: 10.3341/kjo.2021.0068. Epub 2021 Oct 12.

Aged Mice Devoid of the M Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease.

Int J Mol Sci. 2021 Jun 7;22(11):6133. doi: 10.3390/ijms22116133.

Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.

Int J Mol Sci. 2021 May 8;22(9):4989. doi: 10.3390/ijms22094989.

The Role of Inflammation in Age-Related Macular Degeneration.

Int J Biol Sci. 2020 Sep 23;16(15):2989-3001. doi: 10.7150/ijbs.49890. eCollection 2020.

Retinal Degeneration and Alzheimer's Disease: An Evolving Link.

Int J Mol Sci. 2020 Oct 2;21(19):7290. doi: 10.3390/ijms21197290.