儿童癌症治疗后对麻疹、腮腺炎、风疹、白喉、破伤风和百日咳的体液免疫
Humoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children.
作者信息
Sundell Susanna, Laine Miia, Järvelä Liisa, Peltola Ville, Vuorinen Tytti, Lähteenmäki Päivi, Schuez-Havupalo Linnea
机构信息
Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Department of Clinical Microbiology, Turku University Hospital and University of Turku, Turku, Finland.
出版信息
Cancer Rep (Hoboken). 2025 May;8(5):e70155. doi: 10.1002/cnr2.70155.
BACKGROUND
Treatment for pediatric malignancies has distinct effects on the immune system.
AIMS
Our aim was to measure humoral immunity to measles, mumps and rubella (MMR), and diphtheria, tetanus and acellular pertussis (DTaP) vaccines after pediatric cancer treatment.
METHOD
We assessed IgG titers of 52 children against the vaccine antigens post-treatment.
RESULTS
After completed primary vaccination series for MMR and DTaP before treatment, post-treatment there was a considerable proportion of patients with below-reference titers against pertussis, diphtheria and tetanus, but only few subjects showed below-reference titers against measles, mumps and rubella. Our findings may have implications when considering re-vaccination policies.
背景
儿童恶性肿瘤的治疗对免疫系统有独特影响。
目的
我们的目的是测量儿童癌症治疗后对麻疹、腮腺炎和风疹（MMR）疫苗以及白喉、破伤风和无细胞百日咳（DTaP）疫苗的体液免疫。
方法
我们评估了52名儿童治疗后针对疫苗抗原的IgG滴度。
结果
在治疗前完成MMR和DTaP的初次疫苗接种系列后，治疗后有相当比例的患者针对百日咳、白喉和破伤风的滴度低于参考值，但只有少数受试者针对麻疹、腮腺炎和风疹的滴度低于参考值。在考虑重新接种疫苗政策时，我们的发现可能具有启示意义。
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