Kaynar Ömer, Polat Tolga, Koç Harun, Ferhatoğlu Yakup, Yilmaz Özlem Özge, Tacal Aslan Beste, Ulucan Korkut, Gómez-Salgado Juan
Department of Coaching Training, Faculty of Sport Sciences, Muş Alparslan University, Muş, Turkey.
Department of Basic Medical Sciences, Faculty of Dentistry, Marmara University, İstanbul, Turkey.
Medicine (Baltimore). 2025 May 16;104(20):e42429. doi: 10.1097/MD.0000000000042429.
For many years, the relationship between genetic variants and athletic performance has been studied in terms of their effect on strength, power, endurance, muscle fiber type and other phenotypes. As a result of such research, many genes have been found to be associated with athletic performance. In this context, the success achieved by skiers from the same tribe living in Muş (Turkey) is thought to be due to a genetic predisposition. Therefore, this study examined the relationship between the α-actinin-3 (ACTN3) gene rs1815739, vascular endothelial growth factor A (VEGF-A) rs2010963, and GA Binding Protein Transcription Factor Subunit Beta1 (GABPB1) rs7181866 polymorphisms and the success achieved by skiers from the Oğlağo tribe. The study included 19 skiers and 130 sedentary individuals from the same tribe. The Chi-squared (χ²) test and power analysis were used to analyze the genotype and allele distributions of ACTN3, VEGF-A, and GABPB1 polymorphisms in the group of skiers and in the control group. As a result of the analysis, no statistically significant difference was found between the genotype and allele distributions of ACTN3 and VEGF-A polymorphisms (P = .0659, .2018), while statistically significant differences were found across the groups in both the genotype and allele distributions of GABPB1 polymorphism (P < .001). In addition, the genotype and allele percentages of the ACTN3 (TT) and VEGF-A (CC) genotypes associated with endurance were found to be high. Summing up, the present study is the first to reveal the effect of genetics on skiing success in a genetically close cohort (Oğlağo tribe, Muş, Turkey). The results obtained were promising in terms of genetics and skiing success, but further studies are needed to deepen this relationship.
多年来，人们一直在研究基因变异与运动表现之间的关系，涉及它们对力量、功率、耐力、肌纤维类型和其他表型的影响。这项研究的结果是，许多基因已被发现与运动表现有关。在这种背景下，生活在土耳其穆什的同一部落的滑雪者所取得的成功被认为是由于遗传易感性。因此，本研究调查了α-辅肌动蛋白-3（ACTN3）基因rs1815739、血管内皮生长因子A（VEGF-A）rs2010963和GA结合蛋白转录因子亚基β1（GABPB1）rs7181866多态性与奥格拉戈部落滑雪者所取得的成功之间的关系。该研究纳入了来自同一部落的19名滑雪者和130名久坐不动的个体。使用卡方（χ²）检验和效能分析来分析滑雪者组和对照组中ACTN3、VEGF-A和GABPB1多态性的基因型和等位基因分布。分析结果显示，ACTN3和VEGF-A多态性的基因型和等位基因分布之间没有统计学上的显著差异（P = 0.0659，0.2018），而GABPB1多态性的基因型和等位基因分布在两组之间均存在统计学上的显著差异（P < 0.001）。此外，发现与耐力相关的ACTN3（TT）和VEGF-A（CC）基因型的基因型和等位基因百分比很高。总之，本研究首次揭示了在遗传关系密切的队列（土耳其穆什的奥格拉戈部落）中基因对滑雪成功的影响。就基因与滑雪成功而言，所获得的结果很有前景，但需要进一步的研究来深化这种关系。
