BACKGROUND

Endoscopic submucosal dissection (ESD) is a common treatment for early esophageal cancer. Although ESD is considered safe, same-day discharge (SDD) is only feasible in selected patients. Therefore, identifying factors associated with the likelihood of SDD is crucial for optimizing patient selection and clinical management.

METHODS

We conducted a retrospective analysis of patients with early esophageal cancer treated with ESD between August 2020 and July 2024. Patients were divided into SDD and non-SDD groups. Preoperative clinical features were compared between the groups. Univariate and multivariate logistic regression analyses were performed to identify independent predictors associated with the feasibility of SDD.

RESULTS

Among 146 patients, 42 (28.8%) were discharged on the same day. Multivariate analysis identified larger lesion size (OR = 2.152, 95% CI: 2.037-2.280, p = 0.008), history of alcohol abuse (OR = 6.507, 95% CI: 3.169-11.211, p = 0.032), and tumor location in the upper esophagus (OR = 7.827, 95% CI: 5.481-14.547, p = 0.023) as significant factors negatively associated with SDD feasibility. Notably, larger lesions were associated with a lower likelihood of SDD.

CONCLUSION

Tumor size, upper esophageal location, and a history of alcohol abuse were identified as independent predictors associated with reduced feasibility of same-day discharge following ESD.