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解毒剂对甲基苯丙胺成瘾中树突状细胞群体的免疫调节作用。

Immunomodulatory effects of detoxification agents on dendritic cell populations in methamphetamine addiction.

作者信息

Mosayebi Ghasem, Moazzeni Seyed Mohammad, Farahani Hadiseh, Solhi Hassan, Rafiei Mohammad, Ghazavi Ali

机构信息

Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.

出版信息

BMC Pharmacol Toxicol. 2025 May 19;26(1):106. doi: 10.1186/s40360-025-00943-x.

DOI:10.1186/s40360-025-00943-x
PMID:40390118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12087069/
Abstract

BACKGROUND AND AIM

Drug abuse can impact the function of immune cells, leading to a compromised immune system response. This study aimed to investigate the immunomodulatory effects of Methamphetamine and its detoxification agents on peripheral blood dendritic cells.

METHODS

A total of 60 participants were enrolled, including 30 individuals with Methamphetamine addiction and 30 matched healthy controls. Participants were assessed at three time points: at the beginning of detoxification, at the end of detoxification, and one-month post-detoxification. Flow cytometry was employed to analyze dendritic cell subsets (CD11c + myeloid dendritic cells and CD123 + plasmacytoid dendritic cells) and surface marker expression (HLA-DR, CD11c, CD123).

RESULTS

The percentages of both CD11c + and CD123 + dendritic cells in peripheral blood were significantly lower in Methamphetamine addicts compared to the control group. Detoxification with Risperidone corrected this reduction, while the combination of Risperidone and Methylphenidate failed to produce any change in the percentage of dendritic cells. The expression of HLA-DR, CD11c, and CD123 markers was downregulated in the dendritic cells of Methamphetamine addicts. Treatment with Risperidone restored these markers, whereas the combination therapy further exacerbated the downregulation of these markers.

CONCLUSION

The findings suggest that detoxification with Risperidone may help ameliorate the immunological disorders associated with Methamphetamine use.

摘要

背景与目的

药物滥用会影响免疫细胞的功能，导致免疫系统反应受损。本研究旨在探讨甲基苯丙胺及其解毒剂对外周血树突状细胞的免疫调节作用。

方法

共招募60名参与者，包括30名甲基苯丙胺成瘾者和30名匹配的健康对照者。在三个时间点对参与者进行评估：戒毒开始时、戒毒结束时和戒毒后一个月。采用流式细胞术分析树突状细胞亚群（CD11c+髓样树突状细胞和CD123+浆细胞样树突状细胞）及表面标志物表达（HLA-DR、CD11c、CD123）。

结果

与对照组相比，甲基苯丙胺成瘾者外周血中CD11c+和CD123+树突状细胞的百分比显著降低。使用利培酮戒毒可纠正这种降低，而利培酮与哌醋甲酯联合使用未能使树突状细胞百分比产生任何变化。甲基苯丙胺成瘾者树突状细胞中HLA-DR、CD11c和CD123标志物的表达下调。利培酮治疗可恢复这些标志物，而联合治疗则进一步加剧了这些标志物的下调。

结论

研究结果表明，使用利培酮戒毒可能有助于改善与甲基苯丙胺使用相关的免疫紊乱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/3fa8de098882/40360_2025_943_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/f8ebac74b48c/40360_2025_943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/1f8de891efab/40360_2025_943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/c57b37566176/40360_2025_943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/5390e7ac4746/40360_2025_943_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/3fa8de098882/40360_2025_943_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/f8ebac74b48c/40360_2025_943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/1f8de891efab/40360_2025_943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/c57b37566176/40360_2025_943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/5390e7ac4746/40360_2025_943_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/12087069/3fa8de098882/40360_2025_943_Fig5_HTML.jpg

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Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.甲基苯丙胺使用障碍的药物治疗：现状与未来靶点
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IL-3: key orchestrator of inflammation.
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