The Persistent Wound: Plasmablastic Lymphoma in a Perianal Fistula.

Plasmablastic lymphoma is an aggressive subtype of diffuse large B-cell lymphoma associated with immunosuppression, particularly in HIV-positive patients. Although rare in HIV-negative individuals, patients with Crohn's disease experience immune dysregulation due to chronic immunosuppression that can predispose them to plasmablastic lymphoma. We present a case of a 54-year-old man with ileocolonic and perianal fistulizing Crohn's disease who developed plasmablastic lymphoma. This case emphasizes the importance of early recognition of plasmablastic lymphoma in patients undergoing chronic immunosuppressive treatment of Crohn's disease, as early diagnosis and timely intervention are crucial for improving outcomes.